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reaction mass of: trisodium 3-(5-(2,6-difluoropyrimidin-4-ylamino)-2-sulfonatophenylazo)-5-(4-fluoro-6-morpholin-4-yl-1,3,5-triazin-2-ylamino)-4-hydroxy-2,7-naphthalenedisulfonate; trisodium 3-(5-(4,6-difluoropyrimidin-2-ylamino)-2-sulfonatophenylazo)-5-(4-fluoro-6-morpholin-4-yl-1,3,5-triazin-2-ylamino)-4-hydroxy-2,7-naphthalenedisulfonate
EC number: 436-890-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- GLP compliance:
- yes
- Type of method:
- thermal analysis
- Remarks:
- differential scanning calorimetry (DSC)
- Decomposition:
- yes
- Decomp. temp.:
- ca. 135 °C
- Remarks on result:
- not determinable
- Conclusions:
- The test substance has no melting point between up to 390°C; exothermic decomposition starting at 135 °C was observed.
- Executive summary:
The determination of the melting point and the screening test for explosive properties by DSC, Mettler-Toledo TA8000, were carried out in closed glass pan and in aluminium pan.
The measurement in a closed glass pan does not show any endothermic effect prior a decomposition of the test substance in the range 140-370 °C, with a decomposition energy of 470 J/g. In an aluminium pan the diagram shows a broad endothermal effect in the range 80210 °C, which can be explained by drying of the test substance. This was further investigated in a separate experment described below. An exothermal decomposition was observed in the range 210-390 °C, with a decomposition energy of 308 J/g.
In an aluminium pan the diagram shows a broad endothermal effect in the range 80-210 °C, which can be explained by drying of the test substance. This result should be verified with the dried substance. For purifying of the test substance the water content was removed by treating the sample at 50 °C ± 5 °C under vacuum for 20 hours.The determination of the melting point / melting range is carried out by differential scanning calorimetry (DSC) (EG-Guideline 92/69/EEC A.1.).
Additionally the result for the thermal decomposition energy in a closed glass pan was verified with the dried test substance.
The test substance was dried at 50 °C under vacuum for 20 hours, the mass loss after this procedure was 9.4 % (the analyzed water content was 9.3 ± 0.1 %, so all water was removed.
The DSC of the dried test substance in a closed aluminium pan shows an exothermal reaction beginning at 145 °C with a strong break at 180 - 185 °C, which can be seen as an opening of the closed aluminium pan caused by inner pressure; possibly a gas evolution coupled with an exothermal decomposition of the test substance had occurred. After this break the exothermal decomposition continued with a similar shape as with the non-dried substance. After the DSC measuring the substance was still a fine powder similar the dried test substance before the DSC measuring, so theresultis: The dried test substance hasno melting point.
To verify the DSC measuring in a closed glass pan for a decomposition energy to be below 500 J/g,a DSC in a closed glass pan was performed with the dried test substance. Now the decomposition energy amounts 456 J/g i.e. it is still below 500 J/g, so the tests on explosive properties still have not to be performed. The decomposition of the test substance in the closed glass pan begins at 135 °C due to a heating rate of 3 K/min; this has to be compared with the beginning of the decomposition shown in the closed aluminium pan at 145 °C (heating rate: 10 K/min).
Reference
The determination of the melting point and the screening test for explosive properties by DSC, Mettler-Toledo TA8000, were carried out in closed glass pan and in aluminium pan.
The measurement in a closed glass pan does not show any endothermic effect prior a decomposition of the test substance in the range 140-370 °C, with a decomposition energy of 470 J/g. In an aluminium pan the diagram shows a broad endothermal effect in the range 80210 °C, which can be explained by drying of the test substance. This was further investigated in a separate experment described below. An exothermal decomposition was observed in the range 210-390 °C, with a decomposition energy of 308 J/g.
In an aluminium pan the diagram shows a broad endothermal effect in the range 80-210 °C, which can be explained by drying of the test substance. This result should be verified with the dried substance. For purifying of the test substance the water content was removed by treating the sample at 50 °C ± 5 °C under vacuum for 20 hours. The determination of the melting point / melting range is carried out by differential scanning calorimetry (DSC) (EG-Guideline 92/69/EEC A.1.).
Additionally the result for the thermal decomposition energy in a closed glass pan was verified with the dried test substance.
The test substance was dried at 50 °C under vacuum for 20 hours, the mass loss after this procedure was 9.4 % (the analyzed water content was 9.3 ± 0.1 %, so all water was removed.
The DSC of the dried test substance in a closed aluminium pan shows an exothermal reaction beginning at 145 °C with a strong break at 180 - 185 °C, which can be seen as an opening of the closed aluminium pan caused by inner pressure; possibly a gas evolution coupled with an exothermal decomposition of the test substance had occurred. After this break the exothermal decomposition continued with a similar shape as with the non-dried substance. After the DSC measuring the substance was still a fine powder similar the dried test substance before the DSC measuring, so the result is: The dried test substance has no melting point.
To verify the DSC measuring in a closed glass pan for a decomposition energy to be below 500 J/g, a DSC in a closed glass pan was performed with the dried test substance. Now the decomposition energy amounts 456 J/g i.e. it is still below 500 J/g, so the tests on explosive properties still have not to be performed. The decomposition of the test substance in the closed glass pan begins at 135 °C due to a heating rate of 3 K/min; this has to be compared with the beginning of the decomposition shown in the closed aluminium pan at 145 °C (heating rate: 10 K/min).
Description of key information
The melting point was examined following EU method A.1 in compliance with GLP.
The test item decomposes before melting (starting at 135 °C).
Key value for chemical safety assessment
Additional information
The test item has no melting point between 25–3900 °C, only exothermic decomposition beginning at 135 °C was observed.
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