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Diss Factsheets
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EC number: 445-890-5 | CAS number: 201290-01-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Short-term toxicity to invertebrates: 48 hour EC50 >250 mg/l (nominal initial concentration in terms of parent substance) (highest concentration tested) (OECD TG 202). The test was conducted using a mixed pre-hydrolysed solution prepared from the registration substance. The observations in this study are attributed to the exposure of test organisms to the hydrolysis products in the test system. The geometric mean concentration of 3-(dihydroxymethylsilyl)propylamine at the EC50 was measured as >87 mg/l. The geometric mean concentration of trimethylsilanol at the EC50 was measured as >115 mg/l (note: hydrolysis product concentrations at the LC50 measured in the mixed pre-hydrolysed solution).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 250 mg/L
Additional information
A 48-h EC50 value of >250 mg/l (nominal) (highest concentration tested) has been determined for the effects of the registration substance on mobility of Daphnia magna. In view of the test media preparation method and exposure regime it is likely that the test organisms were exposed predominantly to the hydrolysis products of the tested substance. The nominal test concentrations are supported by substance-specific analysis of two of the hydrolysis products and concentrations ranged between 80 -90% of nominal equivalent, consistent with the expectations of extensive hydrolysis in the test media prior to the start of the test.
The relevent 48 hour geometric mean measured EC50 values for two of the the hydrolysis products are:
>87 mg/l for 3-(dihydroxymethylsilyl)propylamine
>115 mg/l for trimethylsilanol (TMS)
Above a concentration of approximately 1000 mg/l, dimeric / oligomeric, cyclic or cross-linked condensation products could potentially form over time in the aqueous test media. Evidence of undissolved material (parent substance or precipitated products) is indicated in the study report for this test (an oily film of undissolved material was observed on test media surface; removed by filtration) and therefore physical effects may have contributed to some extent to the mobility effects in the test. The use of the E(L)C50 value as a measurement of intrinsic toxicity represents a conservative interpretation of the test findings.
There is no basis to expect that ethanol present in the test system would have significantly influenced the results of the test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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