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EC number: 280-489-7 | CAS number: 83567-04-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- From March 17, 1999 to March 19, 1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- RA study
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Remarks:
- TOC determination
- Details on sampling:
- Analysis of the only test concentration plus a control at start and after 48 h of exposure
- Vehicle:
- no
- Remarks:
- direct weighing
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Species: Daphnia magna STRAUS, parthenogenetic females
Origin of the species: cloned at the Federal Health Office (BGA) in Berlin
Test animals: laboratory bred at Bayer AG Lever-kusen
Age: 0 - 24 h - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 15.1 °dH
- Test temperature:
- 20.3 - 20.7
- pH:
- 7.8
- Dissolved oxygen:
- 8.1 mg/L O2
- Nominal and measured concentrations:
- 0 and 100 mg/L (measured)
- Details on test conditions:
- Cylindrical test vessels: diameter 4.0 cm, height 6.5 cm
10 daphnids per vessel (in duplicate)
20 mL test medium
Not ventilated
Observations: mobility after 24 and 48 h - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 80 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Remarks:
- 80 mg/L of the organic components is equivalent to 98 mg/L of the test substance including inorganic components
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- No effects observed
- Results with reference substance (positive control):
- -
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the mean measured 48 h EC0 of the substance in Daphnia magna was determined to be greater than 80 mg/L of the organic components (equivalent to 98 mg/L of the substance including inorganic components). The EC50 could not be determined due to absence of any adverse effects.
- Executive summary:
A study was conducted to determine the short-term toxicity of the read-across substance to aquatic invertebrates according to EU Method C.2, in compliance with GLP. Daphnia magna were exposed for 48 h to the test substance at concentrations of 0 and 100 mg/L. Mobility was assessed daily. Analytical verification of test concentrations was conducted by TOC determination. There were no immobile daphnids in the test group. Under the study conditions, the mean measured 48 h EC0 of the substance in Daphnia magna was determined to be greater than 80 mg/L of the organic components (equivalent to 98 mg/L of the test substance including inorganic components) (Caspers, 1999). The EC50 could not be determined due to absence of any adverse effects.
Reference
Description of key information
Under the read-across study conditions, the mean measured 48 h EC0 of the substance in Daphnia magna was determined to be greater than 80 mg/L of the organic components (equivalent to 98 mg/L of the test substance including inorganic components). The EC50 could not be determined due to absence of any adverse effects.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
A study was conducted to determine the short-term toxicity of the read-across substance to aquatic invertebrates according to EU Method C.2, in compliance with GLP. Daphnia magna were exposed for 48 h to the test substance at concentrations of 0 and 100 mg/L. Mobility was assessed daily. Analytical verification of test concentrations was conducted by TOC determination. There were no immobile daphnids in the test group. Under the study conditions, the mean measured 48 h EC0 of the substance in Daphnia magna was determined to be greater than 80 mg/L of the organic components (equivalent to 98 mg/L of the test substance including inorganic components) (Caspers, 1999). The EC50 could not be determined due to absence of any adverse effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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