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EC number: 944-341-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity to aquatic organisms was not experimentally determined for CaIDHA, but there are available data from studies on the source substances: chelating agent - IDHA, Ca(2Na)EDTA and on other IDHA’s salts as well.
Acute toxicity to fish
Acute toxicity to fish was experimentally determined for chelating agent IDHA and its salts: FeNaIDHA, Cu(2Na)IDHA, Mn(2Na)IDHA, Zn(2Na)IDHA. None of the substances showed a high toxicity.
The assessment of the acute toxic effects (mortality) of IDHA chelating agent on a freshwater fish species (Brachydanio rerio) under static test conditions was conducted according to test method which is in most parts identical with OECD Guideline 203. No mortality or any abnormal swimming behaviour were observed. The LCO(acute fish toxicity) of IDHA, sodium salt value for the fish is ≥ 100 mg/l (nominal) and ≥ 82.6 mg/I (calculated) (Bayer, 1997). All metal-IDHA complexes Fe(Na)IDHA, Zn(2Na)IDHA, Cu(2Na)IDHA and Mn(2Na)IDHA were investigated according to OECD 203 with Oncorhynchus mykiss, resulting in a nominal LC50(96h) value of > 100 mg/L (Nierzędska, 2007; Fochtman, 2009; Swierkot, 2011; Konfederak, 2013a). The LC50 (96h) values for CaCl2 for fish Pimephales promelas is 4630 mg/l, for Lepomis macrochirusis 9500-11300 mg/l and for Gambusia affinisis 13400 mg/l.
Acute toxicity to invertebrates
The EC100(48h) value > 100 mg/L is reported for Fe(Na)IDHA (Nierzędska, 2007), EC50(48h) > 100 mg/L is reported for Mn(2Na)IDHA (OECD 20, Konfederak, 2013b ), EC50(48h) > 38 mg/L is determined for Cu(2Na)IDHA (OECD 202, Konfederak, 2011) and EC50(48h) > 3.16 mg/L is determined for Zn(2Na)IDHA (Fochtman, 2009), a low to medium toxicity potential is predicted for aquatic invertebrates for IDHA metal-complexes.
There are seven acute toxicity data available for Cladocera. The lowest 48-hour EC50 was 1062 mg/L for Daphnia magna (Koopman at all, 1986 cited in INCHEM, 2002). The acute toxicity studies with other invertebrates showed LC50 or EC50 values in the range of 780-44400 mg/L.
Acute toxicity to algae
A low aquatic toxicity potential towards green algae was determined for iron, copper and manganese IDHA complexes. Cu(2Na)IDHA showed no toxicity potential towards fresh water algae and EC50(72h) > 250 mg/L. Similar result has been obtained with Mn(2Na)IDHA in Pseudokirchneriella subcapitata (ErC50(72h) = 598 mg/L and EyC50(72h) of 108.95 mg/L. For FeNaIDHA in OECD test no. 201 the values ExC50/72 h and EyC50/72 h above 72.3 mg/L were established based on measured concentrations. The worst results were for Zn(2Na)IDHA. The nominal value are: ErC50(72h) = 255.97 mg/L and EyC50(72h) of 8.01 mg/L, the measures values are: ErC50(72h) = 4.81 mg/L and EyC50(72h) of 0.86 mg/L.
There is one study for CaCl2 with fresh water algae, Selenastrum capricornutum, which was conducted according to OECD guideline 201. The 72-hour EC50 and EC20 obtained on the basis of biomass from the study were 2900 and 1000 mg/L, respectively. The 72-hour EC50 and EC20 obtained on the basis of growth rate were ≥ 4000 mg/l and 2700 mg/l respectively (INCHEM, 2002).
Acute toxicity to microorganism
According to Column 2, section 9.1.4. of Annex VIII od REACH Regulation the study does not need to be conducted as the target substance Ca(2Na)IDHA is found to be readily biodegradable.
Additional information
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