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Diss Factsheets
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EC number: 202-440-0 | CAS number: 95-68-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Several bacterial reverse mutation assay (Ames test) have been performed on 24 -Xylidine covering the strains Salmonella typhimurium TA98, TA100, TA102, TA1535, TA1537, TA1538 and TA2637. There was no increase in the number of revertant colonies with any of the tester strains without metabolic activation. In the presence of metabolic activation the test substance was mutagenic.
In two mammalian in vitro chromosome aberration studies and an in vitro UDS assay the genotoxic potential of m-Xylidine was examined using Chinese hamster cells and primary hepatocytes, negative results in the absence of metabolic activation were obtained for the CHO cells and positive in case of the of the presence of metabolic activation. Mutagenic properties were obtained from the UDS assay.
From the results obtained with the genotoxicity studies it can be concluded, that m-Xylidine is not mutagenic in without metabolic activation but genotoxic in the presence of metabolic activation.
Short description of key information:
- Ames test: negative without metabolic activation/positive with metabolic activation (3 studies)
- in vitro Chromosome Aberration study in CHO cells: negative without metabolic activation/positive with metabolic activation (2 studies)
- in vitro UDS assay: positive
Endpoint Conclusion:
Justification for classification or non-classification
There are only in vitro studies available to give hint on the genotoxic properties of 2,4-Xylidine. It was shown that the substance does not show any mutagenic effect in the absence of metabolic activation. In the presence of S9 mix m-Xylidine gave a positive response. Based on the existing limited data and considering that these were obtained from in vitro studies exclusively which give only a hint of possible genotoxic mechanisms but fail to reflect the in vivo situation no statement on classification/non-classification with reference to the genotoxicity can be made.
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