Registration Dossier
Registration Dossier
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EC number: 219-440-1 | CAS number: 2437-25-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only 1-page summary was made available for this Guideline study performed under GLP.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- not specified
- GLP compliance:
- yes
- Remarks:
- (Clariant information)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dodecanenitrile
- EC Number:
- 219-440-1
- EC Name:
- Dodecanenitrile
- Cas Number:
- 2437-25-4
- Molecular formula:
- C12H23N
- IUPAC Name:
- dodecanenitrile
- Details on test material:
- Name: C12-Nitril
Synomyms: Laurylnitrile; Dodecanenitrile
CAS no.: 2437-25-4
Structural formula: C12 H23 N
Purity: > 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- none
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- vegetable oil
- Remarks:
- Sesame oil
- Details on oral exposure:
- Concentration: 20% in sesame oil
- Doses:
- Dose level: 2000 mg/kg BW
- No. of animals per sex per dose:
- Not indicated
- Control animals:
- no
- Details on study design:
- No details provided
- Statistics:
- not applicable.
Results and discussion
- Preliminary study:
- No mortality observed in neither male or female animals. Symptoms (not sopecified) of toxicity were observed.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No
- Clinical signs:
- other: Yes (not specified)
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 > 2000 mg/kg bw
- Executive summary:
Dodecanenitril was evaluated for acute oral toxicity according to OECD 401 and EU 84/449/EEC B.1 guidelines in male and female Wistar rats in a limit test procedure. Animals were dosed with 2000 mg/kg bw of Dodecanenitrile as 20% solution in sesame oil.
Symptoms of toxicity were observed, but no mortality occurred.
In conclusion: LD50 > 2000 mg/kg bw.
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