Registration Dossier
Registration Dossier
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EC number: 203-506-1 | CAS number: 107-59-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicity data submissions
- Author:
- Parent, R.A.
- Year:
- 2 000
- Bibliographic source:
- International Journal of Toxicology, 19(5):331-373
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- tert-butyl chloroacetate
- EC Number:
- 203-506-1
- EC Name:
- tert-butyl chloroacetate
- Cas Number:
- 107-59-5
- Molecular formula:
- C6H11ClO2
- IUPAC Name:
- tert-butyl chloroacetate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- air
- Duration of exposure:
- 4 h
- Concentrations:
- 688, 1021, 1471, 3054, 4313 and 5754 mg/m³
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: presumably daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathological changes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 4.738 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: equivalent to 4738 mg/m³
- Mortality:
- 688-1471 mg/m³: 0%
3054 mg/m³: 10%
4313 mg/m³: 40%
5754 mg/m³: 100% - Clinical signs:
- other: Clinical signs at 1021 mg/m³ and above included piloerection, ungroomed fur, laboured breathing, reduced motility, tremor, serous nasal discharge, reddened noses, pallor, cyanosis, prostration. Onset of symptoms was recgnized 4 h after start of inhalation
- Gross pathology:
- Necropsy of dead animals revealed lung edema and emphysema; hydrothorax; pale spleen, kindneys and liver; a reddening of glandular stomach; and rhinarium. Necropsy at day 14 revealed strong emphysema of the lungs with some liverlike areas at 1021 mg/m³ and above.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The approximate acute LC50 combined for males and females is 4738 mg/m³ air (equivalent to 4.738 mg/L air).
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