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EC number: 228-544-6 | CAS number: 6291-84-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from NTRL
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Initial submission: Letter from Eastman Kodak Co to USEPA Regarding Basictoxicity of 3-methylaminopropylamine with Attachments and Cover Letter dated 9/4/92.
- Author:
- NTRL
- Year:
- 1 992
- Bibliographic source:
- OTS0555335, NTRL, dated 9/4/92
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute inhalation toxicity study of 3-Methylaminopropylamine in rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 3-aminopropylmethylamine
- EC Number:
- 228-544-6
- EC Name:
- 3-aminopropylmethylamine
- Cas Number:
- 6291-84-5
- Molecular formula:
- C4H12N2
- IUPAC Name:
- (3-aminopropyl)(methyl)amine
- Details on test material:
- SMILES:CNCCCN
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 3-Methylaminopropylamine
- Molecular formula (if other than submission substance): C4H12N2
- Molecular weight (if other than submission substance): 88.1528 g/mole
- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- 7.2 µm
- Geometric standard deviation (GSD):
- 1.41
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: stainless steel and glass inhalation chambers
- Exposure chamber volume: 420 liters.
- Method of holding animals in test chamber: whole body
- Source and rate of air: Atmospheres were produced by passing air over the surface of the liquid contained in a three necked flask maintained at 35° C tor 61 mg/m and 50° C for 189.3, mg/m3 .
- Method of conditioning air:
- System of generating particulates/aerosols: Vapor laden air exiting the flask vas diluted at a T at which point a chemical or physical reaction occurred resulting in the production of an aerosol.
- Method of particle size determination: Royco Analyzer over the course or exposure resulted in a stable distribution with an aerodynamic mass median diameter of 7.2µm and geometric standard deviation of 1.41.
- Treatment of exhaust air:
- Temperature, humidity, pressure in air chamber:
TEST ATMOSPHERE
- Brief description of analytical method used: Approximately 82% of the particles was less than 10 um in diameter. Chamber concentrations were determined every 0.5 hour by gas chromatography of sample collected in midget impingers.
- Samples taken from breathing zone: yes
VEHICLE
- Composition of vehicle (if applicable):
- Concentration of test material in vehicle (if applicable):
- Justification of choice of vehicle:
- Lot/batch no. (if required):
- Purity:
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution:
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.):
CLASS METHOD (if applicable)
- Rationale for the selection of the starting concentration: - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- by gas chromatography
- Duration of exposure:
- 6 h
- Remarks on duration:
- not specified
- Concentrations:
- 0.0, 0.61 and 189.3 mg/m3
- No. of animals per sex per dose:
- Total: 12
0.0 mg/m3 : 4
0.61 mg/m3 : 4
189.3 mg/m3 : 4 - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: No data
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data
- Other examinations performed: Mortality was observed. - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 189.3 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality observed at 189.3 mg/m3
- Clinical signs:
- other: not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LC50 was considered to be > 189.3 mg/m3 when rat was exposed with 3-aminopropylmethylamine by Whole body inhalation for 6 hours.
- Executive summary:
The acute inhalation toxicity study, rat were exposed with 3-aminopropylmethylamine in the concentration of 0.0, 0.61 and 189.3 mg/m3by Whole body inhalation for 6 hours.No mortality observed at189.3 mg/m3. Therefore, LC50 was considered to be > 189.3 mg/m3when rat was exposed with3-aminopropylmethylamineby Whole body inhalation for 6 hours.
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