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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Reference
Reference Type:
publication
Title:
Fragrance Material Monograph for Allyl butyrate
Author:
Edited by D. L. J. Opdyke
Year:
1977
Bibliographic source:
Food and Cosmetics Toxicology, Volume 15, Issue 6, December 1977, Pages 613-614

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin irritation study of Allyl butyrate (CAS No: 2051-78-7) was conducted on human subjects to determine the degree of skin irritancy caused by the chemical under occlusive condition.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Allyl butyrate
EC Number:
218-129-8
EC Name:
Allyl butyrate
Cas Number:
2051-78-7
Molecular formula:
C7H12O2
IUPAC Name:
prop-2-en-1-yl butanoate
Test material form:
liquid
Details on test material:
Name of the test chemical: 2-Propen-1-yl butanoate
Common name: Allyl butyrate
Molecular Formula: C7H12O2
Molecular Weight: 128.17 g/mol
Substance Type: Organic
Physical State: Liquid
Specific details on test material used for the study:
Name of the test chemical: 2-Propen-1-yl butanoate
Common name: Allyl butyrate
Molecular Formula: C7H12O2
Molecular Weight: 128.17 g/mol
Substance Type: Organic
Physical State: Liquid

Test animals

Species:
other: Human
Strain:
other: Not applicable
Details on test animals or test system and environmental conditions:
no data available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: Petrolatum
Controls:
not specified
Amount / concentration applied:
4%
Duration of treatment / exposure:
48 hours
Observation period:
48 hours
Number of animals:
no data available
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
Moderate irritation was observed

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
The test material Allyl butyrate (CAS No: 2051-78-7) was considered to be moderately irritating to the skin of human subjects.
Executive summary:

Skin irritation study ofAllyl butyrate(CAS No: 2051-78-7) was conducted on human subjects to determine the degree of skin irritancy caused by the chemical.

 

Each subject was treated with 4% ofAllyl butyratein petrolatum dermally for 48 hours under a closed path patch.

 

Since low grade irritation responses were observed after a 48-hr closed-patch, the chemicalAllyl butyrate(CAS No: 2051-78-7)was considered to be irritating to theskin of human subjects.