5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-

Guidance on Safe Use

First-aid measures

Eye contact Rinse immediately with plenty of water for at least 15 minutes.  Keep eye wide open while  rinsing.  Obtain medical attention.  

Skin contact  Take off contaminated clothing and shoes immediately.  Wash off immediately with plenty  of water for at least 15 minutes.  Obtain medical attention.  Discard contaminated clothing or wash before re-use.

Inhalation Move to fresh air.  Oxygen or artificial respiration if needed.  If exposed or concerned: Get medical attention/advice.  

Ingestion Do NOT induce vomiting.  If exposed or concerned: Get medical attention/advice.  

Notes to Physician Medical conditions aggravated include:  liver disorders, vascular disorders, bleeding, oedema.  This product has been reported to interact with the following medications: drugsthat inhibit cytochrome P-450, cardiovascular drugs, anticoagulants.  Material not fully tested

Medical Surveillance The need for a pre-placement physical examination and history for employees with potential exposure to this compound is to be evaluated by a physician that is thoroughlyknowledgeable about both the toxicity of this compound and the extent of work placeexposure.  Baseline testing would include: a complete blood count with differential, EKG, a blood test for liver function.  Based on opportunity for exposure and duration of exposure a periodic follow-up examination may be considered.  It is recommended that the content be similar to the pre-placement exam.  

Employees who are pregnant, are breast-feeding, or who are concerned with other reproductive issues should be encouraged to consult with the occupational health physician monitoring worker's health.  

Fire-fighting measures

Extinguishing Media  Suitable extinguishing media:  Dry chemical, Water spray, Foam  Unsuitable extinguishing media:  Do NOT use water jet.

Protection of  Firefighters

Specific hazards:  Developmental toxicant  Reproductive toxicant  

Protective equipment:  Use personal protective equipment.  In the event of fire, wear self-contained breathing apparatus.  

Hazardous Combustion Products:  carbon oxides (COx), nitrogen oxides (NOx), sulphur compounds, and, gaseous hydrogen chloride (HCl).

Further Information:  HCl gas can form flammable or explosive mixtures with alcohols or metals.  In the event of fire and/or explosion do not breathe fumes.

Other information Decontaminate protective clothing and equipment before reuse.  Avoid generating dust; fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.  

Accidental release measures

Personal precaution  Examples include tightly fitting safety goggles, disposable lab coat of low permeability with cuffs, double gloves and shoe covers.  Wear respiratory protection.  Depending on the nature of the spill (quantity and extent of spill) additional protective clothing and equipment such as a self-contained breathing apparatus may be needed.  

Environmental precautions

Prevent release to drains and waterways.  Prevent release to the environment.  

Containment Methods  Wet down any dust to prevent generation of aerosols, if appropriate.  Cover with suitable material.  

Cleanup Methods  Spill prevention procedures and a spill response procedure should be implemented.

Contain and collect spillage and place in container for disposal according to local regulations.  Clean spill area with a deactivating solution (if available) followed by detergent and water after spill pick-up.  Handle waste materials, including gloves, protective clothing, contaminated spill cleanup material, etc., as appropriate for chemically and pharmacologically similar materials.  

Other information Dust deposits should not be allowed to accumulate on surfaces, as these may form an  explosive mixture if they are released into the atmosphere in sufficient concentration.

Avoid dispersal of dust in the air (i.e., clearing dust surfaces with compressed air).  Nonsparking tools should be used.  

Handling and storage

Handling Precautions  Highly potent material.  Avoid exposure - obtain special instructions before use.  Avoid formation of dust and aerosols.  Keep away from heat and sources of ignition.  Minimize dust generation and accumulation.  Routine housekeeping

should be instituted to ensure that dusts do not accumulate on surfaces.  Dry powders can build static electricity charges when subjected to the friction of transfer and mixing operations.  Provide adequate precautions, such as electrical grounding and bonding, or inert atmospheres.  

Prevent release to drains and waterways.  

Store in sturdy containers appropriate to maintain the integrity of this material for its intended use.  Store in plastic bags in fiber drums.  

Storage Conditions  Store at room temperature.  Keep away from heat, sparks and flames.  Protect against light.

Store over dessicant material.  Avoid moisture.  

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

UN3077

Shipping information

Proper shipping name and description:

Environmentally hazardous substance, solid, n.o.s.

Chemical name:

Thiazolecarboxamide Derivative

Language:

English

Labels:

9

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

UN3077

Shipping information

Proper shipping name and description:

Environmentally hazardous substance, solid, n.o.s.

Chemical name:

Thiazolecarboxamide Derivative

Language:

English

Labels:

9

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

UN3077

Shipping information

Proper shipping name and description:

Environmentally hazardous substance, solid, n.o.s.

Chemical name:

(Thiazolecarboxamide Derivative)

Labels:

9

Marine pollutant

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

UN3077

Shipping information

Proper shipping name and description:

Environmentally hazardous substance, solid, n.o.s.

Chemical name:

Thiazolecarboxamide Derivative

Labels:

9

Remarks

SpecialProvisions

Exposure controls / personal protection

Respiratory Protection

Use and selection of respiratory protection is based upon engineering controls in use and potential for aerosol generation.  When engineering controls are not sufficient control exposure, wear an approved respirator with NIOSH Class 100 or high efficiency particulate (HEPA) filters or cartridges (EN 140/EN 136) when exposures are up to 10 times the exposure control guideline.   Wear a loose-fitting (Tyvek or helmet type) HEPA powered-air purifying respirator (PAPR) (EN 12941) when exposures are 10-25 times the exposure control guideline.   Wear a full facepiece negative pressure respirator with Class 100 or HEPA filters (EN 136) when exposures are 25-50 times the exposure control guideline.   Wear a tightfitting, full facepiece HEPA PAPR (EN 12942) when Exposures are 50-100 times the exposure control guideline. Wear a hood-shroud HEPA PAPR (EN 12941) or full facepiece supplied air respirator (EN139) operated in a pressure demand or other positive pressure mode when exposures are 100-1000 times the exposure control guideline.

Eye Protection

Safety glasses with side-shields are recommended (EN 166).    Face shields or chemical safety goggles (EN 166) may be required if splash potential exists or if corrosive materials are present.   Note: Choice of eye protection may be influenced by the type of respirator which is selected.  

Hand Protection

Wear gloves at all times when handling containers, including when unpacking, inspecting or  transporting within a facility.  Impervious gloves are recommended. (EN 420, EN 374).   Double gloving for all manufacturing personnel potentially in direct contact with the compound should be considered.  If material is handled in solution, the solvent should also be considered when selecting protective clothing material.  

Skin and Body Protection

Wear a laboratory coat (EN 340) when handling quantities up to 500 grams.  For quantities upto 1 kilogram, wear disposable laboratory coat (EN 340) or coverall of low permeability (EN 1149-1) .  For quantities over 1 kilogram and manufacturing operations, wear disposable coverall of low permeability (EN 1149-1) and disposable shoe covers.  

Hygiene

Wash hands and face before breaks and immediately after handling the product.  

Environmental  exposure controls

Prevent release to drains and waterways.  

Stability and reactivity

Chemical Stability  

Stable under normal conditions.  

Hazardous Decomposition products

Hazardous decomposition products formed under fire conditions.: carbon oxides (COx),

nitrogen oxides (NOx), sulphur compounds, and, gaseous hydrogen chloride (HCl).

Minimum  Ignition Energy > 25 - < 50 mJ    

Material has moderate sensitivity to ignition as a dust cloud.  

Sensitivity to static discharge/Dust exp.  

Explosion Severity Factor

197 m.b_/s

St1

Material exhibits weak to moderate explosion characteristics if ignited as a dust cloud

Volume Resistivity (ambient)

150E+12 ohm.m

Material is highly susceptible to accumulating static charges during processing

Charge decay time (ambient)  5.5 H

Ignition temperature

> 600 °C    

Layer Decomposition

Material begins to exhibit exothermic activity at a temperature of: 302 °C.  Maintain maximum process temperatures at least 20°C below this onset

temperature.

Powder handling equipment such as dust collectors, dryers, and mills may require additional protective measures (e.g. explosion venting, inerting, etc.).  Provide suitable bonding and grounding for containers and process equipment to control accumulation of static charges. NOTE: THIS DATA IS REPRESENTATIVE FOR THE SPECIFIC PROCESS STATE OFTHE MATERIAL NOTED ON THIS SDS ONLY.  Dust explosion severity risk can vary upon processing or environmental change (e.g. milling, micronizing, sieving, blending or heating can increase the risk of explosion), and may require additional dust explosion testing

Disposal considerations

Disposal by incineration is recommended