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EC number: 267-500-0 | CAS number: 67874-72-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute rat oral toxicity in a similar to OECD TG 401 study: LD50 >= 5000 mg/kg bw
Acute rabbit dermal toxicity: similar to OECD TG 402: LD50 > 5000 mg/kg bw
Acute inhalation information using route to route extrapolation: LC50 > 13000 mg/m3
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The study is considered to be a reliability 2 study since it predates GLP but is similar to OECD TG 401.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The study is considered to be a reliability 2 study since it predates GLP but is similar to OECD TG 402.
Additional information
Acute oral toxicity
Rat_Key: In a pre-GLP acute toxicity study similar to OECD 401, 10 rats were orally exposed to 5000 mg/kg bw test substance. All animals survived the 14 -day observation period. Under the conditions of the test the acute oral LD50 was determined to be >5000 mg/kg bw in rats.
Mice_Supporting: In a pre-GLP acute toxicity study similar to OECD 401, 10 mice per sex/dose were orally exposed to 3000, 4000, 6000, and 7000 mg/kg bw test substance. Animals were observed for 14 days and clinical signs were reported. After 14-days survivors were euthanized and necropsied and the gross pathology was reported. Mean body weights of male and female mice were increased after 14 days in all dose groups. Clinical signs were decreased activity, ataxia, salivation, urinary incontinence, and convulsions. 2/10, 5/10, 6/10 and 9/10 animals died after administration of 3000, 4000, 6000, and 7000 mg/kg bw test substance, respectively. Under the conditions of the test the LD50 was determined to be 4388 mg/kg bw with a 95% confidence interval of 1926 – 8564 mg/kg bw.
Rat_Additional, Summary information only: A recent acute oral toxicity study (2015) is available in the database of Research Institute for Fragrance Materials (RIFM). In an OECD TG 420 study the LD50 was found to be > 2000 mg/kg bw.
Acute inhalation toxicity
Using route to route extrapolation the inhalation toxicity can be derived as follows: an oral LD50 of > 5000 mg/kg bw can be roughly converted into > 13000 mg/m3 (CLP guidance, pg. 255, section, 3.1.3.3.3, 2015). The maximum saturated vapour pressure for the substance is (4.24 x 212,330 MW (mg/mol)) / (8.3 (R, gas constant) x 293 (°K)) = 370 mg/m3. This means that Coniferan cannot reach a concentration higher than 370 mg/m3. Therefore an LC50 for inhalation cannot be reached and no classification and labelling is needed for the acute inhalation route.
Acute dermal toxicity study
In a pre-GLP acute toxicity study similar to OECD 402, 10 rabbits were dermally exposed to 5000 mg/kg bw test substance. All animals survived the 14 -day observation period. Under the conditions of the test the dermal LD50 was determined to be >5000 mg/kg bw in rabbits.
Justification for classification or non-classification
Based on the results of the acute oral and dermal toxicity tests and the derived inhalation acute toxicity the substance does not have to be classified for acute toxicity in accordance with Regulation (EC) No. 1272/2008 and its updates.
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