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Diss Factsheets
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EC number: 227-105-6 | CAS number: 5657-17-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summary information only, very limited information is available for the interpretation of the results.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 962
- Report date:
- 1962
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- This study followed internal Dow procedures.
- GLP compliance:
- no
- Test type:
- other: conclusion from other data
Test material
- Reference substance name:
- Trisodium 2-(carboxylatomethyl(2-hydroxyethyl)amino)ethyliminodi(acetate)
- EC Number:
- 205-381-9
- EC Name:
- Trisodium 2-(carboxylatomethyl(2-hydroxyethyl)amino)ethyliminodi(acetate)
- Cas Number:
- 139-89-9
- Molecular formula:
- C10H18N2O7.3Na
- IUPAC Name:
- trisodium [{2-[bis(carboxylatomethyl)amino]ethyl}(2-hydroxyethyl)amino]acetate
- Details on test material:
- - Name of test material (as cited in study report): Versenol 120, Glycine: N-(carboxy methyl)-N'-(2-hydroxyethyl)- N,N'-ethylenedi-trisodium salt
- Molecular formula (if other than submission substance): C10H15N2Na3O7
- Molecular weight (if other than submission substance): 344.20
- Physical state: liquid
- Analytical purity: 41.2%
- Color: yellow
- All other template details: Not reported
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Conclusion is based on the skin contact test
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: ear, belly
- Number of exposures: 9 to intact ear and belly, 1 to abraded belly
- All other template details: Not reported - Duration of exposure:
- Up to 21 days
- Doses:
- Not reported
- No. of animals per sex per dose:
- Not reported
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: up to 21 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: yes/
- Other examinations performed: not reported - Statistics:
- Not reported
Results and discussion
- Preliminary study:
- There is no indication from the skin irritation tests conducted that this material is absorbed through the skin in toxic amounts.
- Mortality:
- Not reported
- Clinical signs:
- other: Not reported
- Gross pathology:
- See Table 1
- Other findings:
- Not reported
Any other information on results incl. tables
Table 1. Summary of skin contact results
Material | Condition of skin | Site | Number of applications | Responses |
Undiluted | Intact | Ear | 9 | Very slight hyperemia. |
Undiluted | Intact | Belly | 9 | Very slight hyperemia. |
Undiluted | Abraded | Belly | 1 | Moderate hyperemia, edema and necrosis after first application, moderate scab formed on the fourth day of exposure, skin healed in 21 days with moderate scar. |
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- There is no indication from the skin irritation tests conducted that this material is absorbed through the skin in toxic amounts.
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