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EC number: 813-928-3 | CAS number: 155810-87-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Reaction product of: 3-hydroxy-5,7-di-tert-butylbenzofuran-2-one with o-xylene
- EC Number:
- 417-100-9
- EC Name:
- Reaction product of: 3-hydroxy-5,7-di-tert-butylbenzofuran-2-one with o-xylene
- Cas Number:
- 181314-48-7
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- During the test samples for analysis were taken from the control, the Cremophor-control, from the supersaturated solution of nominally 100 mg/l and its filtrate.
Sampling: Frequency at t=Oh and t=48h.
Volume 10 ml from the approximate centre of the test vessel.
Storage The samples were stored in a deep-freeze until analysis.
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- According to data of the sponsor, water solubility of the test substance was < 0.05 mg/l. Therefore, the test substance solution was prepared by mixing 30.4 and 30.0 mg of test substance with 30.2 and 29.9 mg of Cremophor EL in 300 ml of ISO-medium, respectively. These dispersions were stirred for ca. 94 hours before the start of the exposure. Subsequently, one of these dispersions was filtered through a paper filter and as such tested, i.e. 2 x 80 ml divided over 2 vessels. From the other stirred dispersion also 2 x 80 ml were taken and tested without filtration. The filtrate was turbid while the unfiltered solution was turbid with larger undissolved test substance particles dispersed through the medium.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Species: Daphnia magna (Crustacea, Cladocera) (Straus, 1820)
Reason for selection: This system has been selected as an internationally accepted species.
Validity of batch: Frequent inspection of the cultures with respect to number of young, appearance of young and parental daphnia and global feeding behaviour.
Characteristics: For the test selection of young daphnia with an age of < 24 hours.
Start of each batch: With newborn animals, i.e. less than 3 days old, by placing about 250 of them into 10 litres of medium in an all-glass culture
vessel.
Maximum age of the cultures: 4 weeks
Renewal of the cultures: After 7 days of cultivation half of the medium twice a week.
Temperature of medium: 18-22°C, constant within + 1°C
Feeding: Daily, a suspension of fresh water algae.
Medium: M4, as prescribed by Dr. Elendt-Schneider (Elendt, B.-P., 1990: Selenium deficiency in Crustacea. An ultrastructural approach to antennal damage in Daphnia magna Straus. Protoplasma 154, 25-33).
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 250 mg/l expressed as CaCO3
- Test temperature:
- 18-22 °C, constant within +- 1°C
- pH:
- 7.9 - 8.1
- Dissolved oxygen:
- 9.3 - 9.5
- Salinity:
- n/a
- Nominal and measured concentrations:
- 100 mg/L nominal filtered - 6 to 19 mg/L measured
100 mg/L nominal unfiltered - 5 to 45 mg/L measured - Details on test conditions:
- According to data of the sponsor, water solubility of the substance was < 0.05 mg/l. Therefore, the test substance solution was prepared by mixing 30.4 and 30.0 mg of test substance with 30.2 and 29.9 mg of Cremophor EL in 300 ml of ISO-medium, respectively. These dispersions were stirred for ca. 94 hours before the start of the exposure. Subsequently, one of these dispersions was filtered through a paper filter and as such tested, i.e. 2 x 80 ml divided over 2 vessels. From the other stirred dispersion also 2 x 80 ml were taken and tested without filtration. The filtrate was turbid while the unfiltered solution was turbid with larger undissolved test substance particles dispersed through the medium.
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 45 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- supersaturated solution
- Details on results:
- Under the conditions of the present study, Daphnia magna were not affected by exposure to a highly supersaturated solution with undissolved test substance particles kept in an unstable dispersion. The 48h-EC50 for immobilization of daphnia was greater than 45 mg/l the maximum attainable concentration of the test substance.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
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