Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 250-078-7 | CAS number: 30168-23-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Acceptable study methodology prior to LLNA acceptance.
Test material
- Reference substance name:
- 4-(tricyclo[5.2.1.02,6]dec-8-ylidene)butyraldehyde
- EC Number:
- 250-078-7
- EC Name:
- 4-(tricyclo[5.2.1.02,6]dec-8-ylidene)butyraldehyde
- Cas Number:
- 30168-23-1
- Molecular formula:
- C14H20O
- IUPAC Name:
- 4-[(8Z)-tricyclo[5.2.1.0^{2,6}]decan-8-ylidene]butanal
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Dupical: T-05481, An.nr.123001, no.146398.
A clear yellow fragrance material.
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Albino SPF
- Sex:
- male
- Details on test animals and environmental conditions:
- Acclimatisation: 3 days.
Individually house in suspended stainless steel cages fitted with wire mesh floors and fronts.
Temperature: 23 +/- 1'C.
Relative humidity: 50 +10%.
12 hour light and dark cycle.
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- other: Freund's Complete Adjuvant
- Concentration / amount:
- 0%
- Day(s)/duration:
- 24 hours
- Route:
- intradermal
- Vehicle:
- propylene glycol
- Concentration / amount:
- 50%
- Day(s)/duration:
- 24 hours
- Adequacy of induction:
- highest concentration used causing mild-to-moderate skin irritation and well-tolerated systemically
- Route:
- intradermal
- Vehicle:
- other: Propylene glycol and Freund's Complete Adjuvant (FCA) (1:1)
- Concentration / amount:
- 50%
- Day(s)/duration:
- 24 hours
- Adequacy of induction:
- highest concentration used causing mild-to-moderate skin irritation and well-tolerated systemically
- Route:
- other: topical
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 100%
- Day(s)/duration:
- 48 hours
- Adequacy of induction:
- not specified
Challenge
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: vaseline
- Concentration / amount:
- 15%
- Day(s)/duration:
- 24 hours
- Adequacy of challenge:
- highest non-irritant concentration
- No. of animals per dose:
- Control: 5 animals.
Dose: 10 animals per dose. - Details on study design:
- Preliminary test:
The intradermal and topical irritancy of a range of dilutions of the test substance were examined.
The maximum concentration suitable for intradermal injection was fouond to be 50% v/v in water, and for topical application 30% w/w in vaseline.
These conditions were used in the main test.
Main test:
Induction was effected in a two-stage operation consisting of firstly, a number of intradermal injections made simultaneously and, secondly, one week later, a closed patch exposure performed over the injection sites.
Three pairs of intradermal injections were made in the clipped area.
After one week, the same area of the skin was close shaved again and topically treated with a 30% dilution of the test substance in vaseline. The patch was covered with PVC foil.
The dressing was left for 48 hours and skin readings were made after removal of the patches.
Challenge procedure:
Animals were challenged two weeks after thye topical induction.
The same area of the skin was close shaved again and topically treated with a 10% dilution of the test substance in vaseline.The patch was covered with PVC foil.
The dressing was left for 24 hours and skin readings were made after removal of the patches at 0, 24 and 48 hours. - Challenge controls:
- The animals were challenged at day 14 after the topical induction.
Dupical was mixed in vaseline. - Positive control substance(s):
- no
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 100%
- No. with + reactions:
- 5
- Total no. in group:
- 10
- Clinical observations:
- Erythema
- Remarks on result:
- not determinable because of methodological limitations
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 0%
- No. with + reactions:
- 1
- Total no. in group:
- 5
- Clinical observations:
- Erythema
- Reading:
- 1st reading
- Group:
- positive control
- Remarks on result:
- not measured/tested
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the experiment Dupical indicated a possible potential for weak sensitisation according to the classification of Magnusson and Kilgman (1970) but study is insufficient in severity or in length of time that signs were observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.