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EC number: 247-878-3 | CAS number: 26651-96-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 14 October 2016 and 28 February 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.3110 (Ready Biodegradability)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: ECHA Guidance for the implementation of REACH, Guidance on information requirements and chemical safety assessment, Chapter R.7b: Endpoint specific guidance, November 2014 (version 2.0)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 7,11-dimethyldodeca-4,6,10-trien-3-one
- EC Number:
- 247-878-3
- EC Name:
- 7,11-dimethyldodeca-4,6,10-trien-3-one
- Cas Number:
- 26651-96-7
- Molecular formula:
- C14H22O
- IUPAC Name:
- (4E,6E)-7,11-dimethyldodeca-4,6,10-trien-3-one
- Reference substance name:
- 3,6,10-trimethylundeca-3,5,9-trien-2-one
- EC Number:
- 214-245-8
- EC Name:
- 3,6,10-trimethylundeca-3,5,9-trien-2-one
- Cas Number:
- 1117-41-5
- Molecular formula:
- C14H22O
- IUPAC Name:
- 3,6,10-trimethylundeca-3,5,9-trien-2-one
- Test material form:
- liquid
Constituent 1
impurity 1
- Specific details on test material used for the study:
- Lot No.: SC00018390
Aspect: yellow liquid
Purity: 89.1% 7,11-dimethyldodeca-4,6,10-trien-3-one (sum of the isomers)
6.4% 3,6,10-trimethylundeca-3,5,9-trien-2-one (sum of the isomers)
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, industrial (adaptation not specified)
- Details on inoculum:
- - Source of activated sludge: Domestic sewage works, Bois-de-Bay, Satigny, Switzerland.
- Sludge was collected in the morning, washed three times in the mineral medium (by centrifuging at 1000 g for 10 minutes, discarding the supernatant and resuspending in mineral medium).
- The sludge was kept under aerobic conditions and used the same day. - Duration of test (contact time):
- 62 d
Initial test substance concentration
- Initial conc.:
- 30 mg/L
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- APPARATUS
- Respirometer: Oxitop Control System
WATER
- Ultrapure water containing less than 5 ppb total organic carbon was used during the study.
STOCK SOLUTIONS
- Solution A: KH2PO4 8.5 g; K2HPO4 21.75 g, Na2HPO4.2H2O 33.4 g; NH4Cl 0.5 g (dissolved in water and made up to 1 L).
- Solution B: CaCl2 27.5 g (dissolved in water and made up to 1 L).
- Solution C: MgSO4.7H2O 22.5 g (dissolved in water and made up to 1 L).
- Solution D: FeCl3.6H2O 0.25 g; concentrated HCl one drop (dissolved in water and made up to 1 L).
MINERAL MEDIUM
- Solution A (50 mL) and deionised water (2000 mL) were mixed and Solution B (5 mL), Solution C (5 mL) and Solution D (5 mL) added before making up to 5 L with deionised water.
DETERMINATION OF DRY WEIGHT OF SUSPENDED SOLIDS
- Two 50 mL samples of the homogenised sludge were taken and water was evaporated on a steam bath, dried in an oven at 105-110 °C for two hours, and weighing the residue.
FLASK PREPARATION
- Test substance samples (13.10 mg, corresponding to 30 mg/L in 437 mL) were weighed in small aluminium boats and added to the contents of the test flasks of the Oxitop.
- For reference substance samples 43.70 mg (corresponding to 100 mg/L in 437 mL of test medium) were weighed in small aluminium boats and added to the contents of the test flasks of the Oxitop.
- Flasks were filled with 432 mL of mineral medium.
- Suspended sludge diluted to a concentration of 2.62 g/L dry matter was added.
- pH of each flask was not measured but assumed to be the same as the mineral medium.
- Two sodium hydroxide pellets were placed in the quivers on top of the bottle.
- The flasks were then closed tightly with the measuring heads and allowed to equilibrate to the test temperature.
- After temperature equilibration, the controller of the instrument starts the data acquisition (time zero of the experiment).
TEST CONDITIONS
- Temperature (20.5°C - 21.7 °C) and stirring were checked daily.
- Oxygen consumption of each flask was recorded daily.
NOMINAL CONCENTRATIONS
- Test material: 30 mg/L
- Reference substance: 100 mg/L
TOXICITY CONTROL
- An optional toxicity control was not performed. The validity of the study was not adversely affected.
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
- Test performance:
- - The activity of the inoculum was verified.
- The repeatability validity criterion (not more than 20% difference between replicates) was fulfilled. Therefore, the test was considered valid.
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 65
- Sampling time:
- 28 d
BOD5 / COD results
- Results with reference substance:
- Degradation of reference substance sodium benzoate exceeded 40 % (after 7 days) and 65 % (after 14 days). For details see Appendix 4 of attached study report 16 - E331.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable, but failing 10-day window
- Conclusions:
- Pseudoisoraldeine A did not significantly inhibit the intrinsic respiration of the inoculum at the test concentration and was considered to be non-toxic to the inoculum at the test concentration.
Pseudoisoraldeine A undergoes 65% biodegradation after 28 days in the test conditions. The 10-day window criterion is not fulfilled (12% biodegradation on day 3 and 50% on day 13). The 10-day time window criterion was developed on the assumption that a test substance is degraded according to a "standard" growth curve in ready biodegradability tests. The OECD Guidelines for Testing of Chemicals, Section 3. Part 1: Principles and strategies related to the testing of degradation of organic chemicals (adopted March 2006), states that if a substance consists of "constituents with different chain-lengths, degree and/or site of branching or stereo-isomers, even in their most purified commencial forms" and "it is anticipated that a sequential biodegration of the individual structures is taking place, then the 10-day window should not be applied to interpret the results of the test". The 10-day time-window should therefore not be appled as a pass / fail criterion for Pseudoisoraldeine A.
Thus, Pseudoisoraldeine A should be regarded as readily biodegradable according to the test based on the biodegration percentage of 65% at day 28. - Executive summary:
The Ready Biodegradabilty of Pseudoisoraldeine A was determined by the Manometric Respirometry test.
Pseudoisoraldeine A did not significantly inhibit the intrinsic respiration of the inoculum at the test concentration and was considered to be non-toxic to the inoculum at the test concentration.
Pseudoisoraldeine A undergoes 65% biodegradation after 28 days in the test conditions. The 10-day window criterion is not fulfilled (12% biodegradation on day 3 and 50% on day 13). The 10-day time window criterion was developed on the assumption that a test substance is degraded according to a "standard" growth curve in ready biodegradability tests. The OECD Guidelines for Testing of Chemicals, Section 3. Part 1: Principles and strategies related to the testing of degradation of organic chemicals (adopted March 2006), states that if a substance consists of "constituents with different chain-lengths, degree and/or site of branching or stereo-isomers, even in their most purified commencial forms" and "it is anticipated that a sequential biodegration of the individual structures is taking place, then the 10-day window should not be applied to interpret the results of the test". The 10-day time-window should therefore not be appled as a pass / fail criterion for Pseudoisoraldeine A.
Thus, Pseudoisoraldeine A should be regarded as readily biodegradable according to the test based on the biodegration percentage of 65% at day 28.
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