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EC number: 246-905-6 | CAS number: 25371-55-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 30 2004 - April 6 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl hydrogen octadecylphosphonate
- EC Number:
- 246-905-6
- EC Name:
- Methyl hydrogen octadecylphosphonate
- Cas Number:
- 25371-55-5
- Molecular formula:
- C19H41O3P
- IUPAC Name:
- methoxy(octadecyl)phosphinic acid
- Reference substance name:
- Octadecylphosphonic acid
- EC Number:
- 225-216-4
- EC Name:
- Octadecylphosphonic acid
- Cas Number:
- 4724-47-4
- Molecular formula:
- C18H39O3P
- IUPAC Name:
- octadecylphosphonic acid
- Reference substance name:
- Dimethyl octadecylphosphonate
- EC Number:
- 246-904-0
- EC Name:
- Dimethyl octadecylphosphonate
- Cas Number:
- 25371-54-4
- Molecular formula:
- C20H43O3P
- IUPAC Name:
- dimethyl octadecylphosphonate
- Test material form:
- solid
Constituent 1
impurity 1
impurity 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Animals were housed individuallyin suspended stainless steel cages. All housing and care were based on the standards recommended by the Guide for the Care and Use of Laboratory Animals. PMI certified Rabbit Chow and municipal tap water treated by reverse osmosis was available ad libitum throughout the studyENVIRONMENTAL CONDITIONSTemperature - 20-22°CRelative Humidity - 44- 60%Light Cycle - 12-hour light / 12-hour dark cycleVentilation - 10-15 air changes/hour
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- 15 seconds
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 3 male New Zealand White rabbits
- Details on study design:
- Three male rabbits were used to evalutae the potential irritant and/or corrosive effects of MMOP. Each of the three rabbits received 0.1 mLK of the neat test article in the conjunctival sac of the right eye. The contralateral ete of each animal remained untreated and served as a control. Test and control eyes were examined for signs of irritation for up to 7 days following dosing.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.78
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.443
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- Exposure to the test article produced corneal opacity in 3/3/ test eyes by the 24-hour scoring interval. The corneal opacity resolved completley in 2/3 test eyes by the 72-hour scoring interval and the remaining eye by the end of day 7. Iritis was noted in 2/3 test eyes by the 24 hour scoring interval by the end of the 24 hour scoring interval and resolved compleley in 1/3 test eyes by 48 hours and in the remaining eye by day 7. Conjunctivitis (redness, swelling and discharge) was noted in 3/3 tet eyes at the 1-hour scoring interval. The conjunctival irritation reslved completley in 3/3 test eyes by day 7. Additional ocular findings included slight dulling of the normal luster of the cornea (2/3 test eyes) and sloughing of the corneal epithelium (1/3 test eyes). All effects were fully reversible by day 7.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the study design MMOP is not considered to be an eye irritant under CLP
- Executive summary:
The potential irritant and/or corrosive effects of MMOP were evaluated on the eyes of New Zealand White rabbits. Each of three rabbits received 0.1mL of the test article in the conjunctival sac of the right eye. the contralateral eye of each animal remained untreated and served as a control. Test and control eyes were examined for signs of irritation for up to 7 days following dosing.
Exposure to the test article resulted in corneal opacity in 3/3 test eyes by the 24 -hour scoring interval which was confirmed by positive fluorescein dye retention. The corneal opacity resolved completely in 2/3 test articles by the 72 -hour scoring interval and i the remaining test eye but study day 7. Iritis was observed in 2/3 test eyes by the 24 -hour scoring iterval and resolved fully in 1/3 test eyes by the 48 -hour scoring pont and in the remaining test eye by study day 7. Conjunctivitis (redness, swelling and discharge) was noted in 3/3 test eyes at the 1 -hour scoring interval, which had fully resolved in 3/3 test eyes by day 7. Additional ocular findings included slight dulling of the normal luster of teh cornea (2/3 test eyes) and sloughing of the corneal epithelium (1/3 test eyes). All effects were fully reversible by day 7.
Based on the EEC labelling criteria. MMOP is not considered to be an occular irritant.
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