Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-489-3 | CAS number: 8052-41-3 A colorless, refined petroleum distillate that is free from rancid or objectionable odors and that boils in a range of approximately 148.8°C to 204.4°C (300°F to 400°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Psychological function changes among maintenance house painters exposed to low levels of organic solvent mixtures.
- Author:
- Lindström K & Wickström G
- Year:
- 1 983
- Bibliographic source:
- Acta Psychiatr Scand, 67(suppl 303): 81-91.
Materials and methods
- Study type:
- cross sectional study
- Endpoint addressed:
- basic toxicokinetics
- acute toxicity: inhalation
- repeated dose toxicity: inhalation
- neurotoxicity
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Cross-sectional study. Questionnaire. 8 neuropsychological tests determining intelligence and psychomotor performance
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Stoddard solvent
- EC Number:
- 232-489-3
- EC Name:
- Stoddard solvent
- Cas Number:
- 8052-41-3
- Molecular formula:
- C10H22
- IUPAC Name:
- stoddard solvent
- Test material form:
- liquid
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- confirmed, but no further information available
- Details on study design:
- In a cross-sectional study, 219 housepainters and 229 reinforcement workers were assessed using 8 neuropsychological tests to determine intelligence and psychomotor performance. The mean exposure period was 22 years with an estimated average level of white spirit of 40 ppm (232 mg/m³) during working hours; exposure indices made for total lifetime exposure and average exposure levels.
- Exposure assessment:
- measured
- Details on exposure:
- Mexp. 22 years with an estimated average level of white spirit of 40 ppm during working hours; exposure indices made for total life-time exposure and average exposure levels
Results and discussion
- Results:
- Among painters, there were significantly increased prevalence of acute symptoms such as nausea, runny noses and malaise. Short-term visual memory and simple reaction time were affected, however, when pre-exposure intellectual level was taken into account, the painters performed more poorly only in the visual memory test.
Applicant's summary and conclusion
- Conclusions:
- In a cross-sectional study, 219 housepainters and 229 reinforcement workers were assessed using 8 neuropsychological tests to determine intelligence and psychomotor performance. The mean exposure period was 22 years with an estimated average level of white spirit of 40 ppm (232 mg/m³) during working hours; exposure indices made for total lifetime exposure and average exposure levels. Among painters, there were significantly increased prevalence of acute symptoms such as nausea, runny noses and malaise. Short-term visual memory and simple reaction time were affected, however, when pre-exposure intellectual level was taken into account, the painters performed more poorly only in the visual memory test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.