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EC number: 219-989-7 | CAS number: 2592-95-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicologic Evaluation of the given test chemical.
- Author:
- Montgomery et al.
- Year:
- 1 992
- Bibliographic source:
- International Journal of Toxicology
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Primary eye irritation study was performed on male New Zealand White rabbits to assess the irritation potential of the test chemical
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-hydroxybenzotriazole
- EC Number:
- 219-989-7
- EC Name:
- 1-hydroxybenzotriazole
- Cas Number:
- 2592-95-2
- Molecular formula:
- C6H5N3O
- IUPAC Name:
- 1H-1,2,3-benzotriazol-1-ol
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): 1- Hydroxybenzotriazole hydrate
- Molecular formula: C6H5N3O
- Molecular weight: 135.126 g/mol
- Substance type: Organic
- Physical state: Solid, crystalline powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.01g (10 mg) undiluted test sample. - Duration of treatment / exposure:
- Duration of exposure: 20 secs (rinsed eyes)
Duration of treatment: 7 days (unrinsed eyes) - Observation period (in vivo):
- 2 and 4 hours, and at 1, 2, 3, and 7 days
- Number of animals or in vitro replicates:
- 2 male rabbits
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes, Approximately 20 seconds after the test material was administered, both eyes of 1 rabbit were rinsed for 1 minute with water.
- Time after start of exposure: 20 seconds after the test material was administered.
SCORING SYSTEM: According to the method of Draize
TOOL USED TO ASSESS SCORE: A biomicroscope and fluorescein stain were used at examinations beginning the day after treatment.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Reversibility:
- fully reversible within: 7 days
- Remarks:
- in the unrinsed eyes
- Remarks on result:
- probability of mild irritation
- Irritant / corrosive response data:
- Both treated eyes initially showed mild conjunctival redness and chemosis with one instance of blood-tinged discharge; these effects resolved by 2 days in the rinsed eye and by 7 days in the unrinsed eye. Mild generalized opacity of the cornea was observed on the day of treatment in the unrinsed eye.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Both treated eyes initially showed mild conjunctival redness and chemosis with one instance of blood-tinged discharge; these effects resolved by 2 days in the rinsed eye and by 7 days in the unrinsed eye. Mild generalized opacity of the cornea was observed on the day of treatment in the unrinsed eye.
Hence, under the experimental test conditions it was concluded that the test chemical was considered to be mildly irritating to the eyes of rabbits and being classified as “Irritating to eyes in Category 2” as per CLP Regulation. - Executive summary:
Primary eye irritation study was conducted on 2 male New Zealand White rabbits to assess the irritation potential of the test chemical. 0.01 g (10mg) of the undiluted test chemical was instilled into the lower conjunctival sac of the right eyes of 2 male New Zealand White rabbits. The left eye served as control. Approximately after 20 seconds of test material administration, both eyes of 1 rabbit were rinsed for 1 minute with water; the eyes of the other rabbit were not rinsed. Irritation was scored at 2 and 4 hours, and at 1, 2, 3, and 7 days. Biomicroscope and fluorescein stains were used at examinations beginning the day after treatment.
Both treated eyes initially showed mild conjunctival redness and chemosis with one instance of blood-tinged discharge; these effects resolved by 2 days in the rinsed eye and by 7 days in the unrinsed eye. Mild generalized opacity of the cornea was observed on the day of treatment in the unrinsed eye.
Hence, under the experimental test conditions it was concluded that the test chemical was considered to be mildly irritating to the eyes of rabbits and being classified as “Irritating to eyes in Category 2” as per CLP Regulation.
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