Registration Dossier
Registration Dossier
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EC number: 910-697-1 | CAS number: -
Endpoint summary
Administrative data
Description of key information
When dissolved in water, the reaction mass of calcium fluoride, calcium sulfate and calcium carbonate will dissociate into Ca2+,CO32-, SO42- and F-. Ca2+,CO32-, SO42- ions are essential to all living organisms (flora and fauna) and their intracellular and extra-cellular concentrations are actively regulated by homeostasis and therefore no bioaccumulation is expected for these ions. For F- ions there is not such a homeostasis mechanism. Studies have been conducted to assess the bioaccumulation potential of NaF. In the key study by the Japanese Ministry of environment, conducted according to OECD 305, bioconcentration factors have been measured at steady state: ≤ 0.66 L/kg when exposed to 5 mg NaF/kg and < 6.4 L/kg when exposed to 0.5 mg NaF/L. Also in a report by RIVM BCF values for fluoride have been reported in the range of < 1 to 7.5 in aquatic plants and 50 - 150 in fish and crustacea. Overall the available data indicate that fluoride has loc BCF values. Fluoride is hence considered not bioaccumulative in accordance with the REACH PBT criteria.
Additional information
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