2-methylpent-2-enal

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1950 - 54

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: No guideline study. No GLP

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Unnamed

Year:

1954

Reference 2

Reference Type:

review article or handbook

Title:

no data

Author:

N.N.

Year:

2011

Bibliographic source:

Registry of Toxic effects Of Chemical Substances (RTECS) - AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54.

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Acute dermal toxicity.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-methylpent-2-enal

EC Number:

210-789-5

EC Name:

2-methylpent-2-enal

Cas Number:

623-36-9

Molecular formula:

C6H10O

IUPAC Name:

2-methylpent-2-enal

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation:2.5 to 3.5 kg
- Fasting period before study: no
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data

IN-LIFE DATES: no data

Administration / exposure

Type of coverage:

occlusive

Vehicle:

other: undiluted

Details on dermal exposure:

The fur is closely clipped over the entire trunk, and the dose, retained beneath an impervious plastic film, contacts about 1/10 of the body surface.

Duration of exposure:

24 hours

Doses:

2 to 10 mL/animal

No. of animals per sex per dose:

4 male animals

Control animals:

no

Details on study design:

The fur is closely clipped over the entire trunk, and the dose, retained beneath an impervious plastic film. contacts about 1/10 of the body surface. After 24 hours contact the film is removed, and mortality is considered complete after 14 additional days.

Statistics:

Limits of +/- 1.96 standard deviations were calculated by method of Thompson:
Thompson, W.R.: Use of Moving Averages and Interpolation to Estimate Median-Effective Dose, Bact. Rev. 11:115, 1947

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

4 000 mg/kg bw

Based on:

test mat.

95% CL:

> 1 960 - < 8 624

Remarks on result:

other: assuming a density of 0.88 g/cm³; equivalent to 4.5 mL/kg bw

Applicant's summary and conclusion

Conclusions:

2-Methyl-2-pentene-1-al showed an acute dermal LD50 of 4000 mg/kg bw in rabbits .