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EC number: 218-737-3 | CAS number: 2222-33-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Authroritative database
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Principles of method if other than guideline:
- These tests are conducted based on OECD-GLP standard and OECD test guidelines to study the short term toxicity to aquatic invertebrates by Acute Immobilisation Test.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 5H-dibenzo[a,d]cyclohepten-5-one
- Molecular formula: C15 H10 O
- Molecular weight: 206.243 g/mol
- Smiles notation: c12c(ccc3c(c1=O)cccc3)cccc2
- Inchl : 1S/C15H10O/c16-15-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)15/h1-10H
- Substance type: Organic
- Physical state: solid - Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea - Test type:
- not specified
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Hardness:
- no data
- Test temperature:
- no data
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- no data
- Nominal and measured concentrations:
- no data
- Details on test conditions:
- no data
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.9 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The short term toxicity to aquatic invertebrates test was performed according to the OECD Guideline 202. The EC50 value of dibenzo[b,f]cyclohepten-1-one (2222-33-5) in Daphnia magna was found to be 1.9 mg/l based on immobilisation effect.
- Executive summary:
The short term toxicity to aquatic invertebrates test was performed according to the OECD Guideline 202. The test was performed on Daphnia magna for 48 hrs using 5H-dibenzo[b,f]cyclohepten-1-one at 1.9 mg/l concentration. After experiment it was determined that the EC50 value of 5H-dibenzo[b,f]cyclohepten-1-one (2222-33-5) in Daphnia magna was 1.9 mg/l based on immobilisation effect. On the basis of CLP regulation 5H-dibenzo[b,f]cyclohepten-1-one (2222-33-5) was considered likely to be toxic to aquatic invertebrates and can be classified in aquatic chronic 2 category based on CLP regulation.
Reference
Description of key information
The short term toxicity to aquatic invertebrates test was performed according to the OECD Guideline 202. The test was performed on Daphnia magna for 48 hrs using dibenzo[b,f]cyclohepten-1-one at 1.9 mg/l concentration. After experiment, the EC50 value of dibenzo[b,f]cyclohepten-1-one (2222-33-5) in Daphnia magna was determined to be 1.9 mg/l based on immobilisation effect.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.9 mg/L
Additional information
The study of 5H-dibenzo[b,f]cyclohepten-1-one to aquatic invertebrate was performed which was summaries with one experimental study and prediction of the chemical as follows:
Short term toxicity to aquatic invertebrates was studied for 5H-dibenzo[b,f]cyclohepten-1-one by J-check (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan,2000).The test was performed in Daphnia magna according to the OECD Guideline 202. The time period for treatment was 48 hrs. After the experiment, the EC 50 value for Daphnia magna by 5H-dibenzo[b,f]cyclohepten-1-one was determined to be 1.9 mg/l on the basis of immobilisation effects.
In prediction done by SSS (2017) using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptorand considering the five closest read across substances, the short term toxicity on aquatic invertebrates was predicted for5H-dibenzo[a,d]cyclohepten-5-one (CAS no 2222-33-5).From prediction the EC50 value was estimated to be 132.63mg/L on the basis of intoxication for Daphnia magna for 48 hrs duration.
Thus based on QSAR prediction, 5H-dibenzo[b,f]cyclohepten-1-one was considered to be non hazardous to aquatic invertebrates but as the experimental study from J-check concluded that 5H-dibenzo[b,f]cyclohepten-1-one was likely to be toxic to aquatic invertebrate. Hence, based on the EC 50 value which is 1.9 mg/l, 5H-dibenzo[b,f]cyclohepten-1-one was classified in aquatic chronic 2 according to the CLP regulations.
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