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Diss Factsheets
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EC number: 701-371-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable well documented study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Principles of method if other than guideline:
- The study was conducted according to an internal BASF method. Test groups consisting of 5 animals/sex/group were treated with several doses of an aqueous suspension of the test substance applied intraperitoneally. After exposure, the animals were observed for a period of 14 d within which time signs of clinical toxicity as well as mortality were monitored and recorded. Animals found dead during the observation period were subjected to necropsy. At conclusion, the surviving animals were also sacrificed for the purpose of necropsy. The LD50 value was estimated on the basis of the observed mortalities.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Heliogengruen D 8730 (solide)
- Analytical purity: ca. 98 %
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
Average body weight at study initiation:
- males: 30 g
- females: 26 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: suspension containing 0.5 % CMC and 1-2 drops Cremophor EL
- Details on exposure:
- Concentration of the test material in vehicle:
- 20 % (2000 mg/kg bw),
- 7 % (700 mg/kg bw)
-Amount of test material applied per gavage:
- 10 ml/kg bw for 2000 mg/kg bw
- 10 ml/kg bw for 700 mg/kg bw - Doses:
- 700, 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals per sex per dose.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: directly, 15 min, 30 min, 1 h, 2 h, 4 h and 5 h after injection, then on day 3, 4, 5, 6, 7, 10, 11, 12 and 13 until conclusion.
- Clinical symptoms and body weight were documented.
- Necropsy of survivors were performed. Deceased animals and those sacrificed at the end of the observation period (on day 14 after dosing) were necropsied.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality of 5 males and 5 females per dose was seen.
- Clinical signs:
- Some symptoms of poisoning (dyspnoea, apathy, spastic walk, stretching, unkempt fur, exsiccosis and poor general condition) were noted within the first 5 hours after application of the test substance. Green unkempt fur and green urine were seen in the 2000 mg/kg bw group on day 3 and 4.
- Body weight:
- The body weight gain was within the normal range, details can be seen in "Remarks on results including tables and figures".
- Gross pathology:
- Autopsy revealed incorporation of substance in the abdomen and coloration of fat tissue.
Any other information on results incl. tables
Table 1: Mean body weight of mice after intraperitoneal application of Heliogengrün D 8730
Dose level [mg/kg bw] |
Males |
Females |
||
700 |
2000 |
700 |
2000 |
|
Day 3 |
30.8 |
33.2 |
29.2 |
24.8 |
Day 7 |
32.8 |
34.4 |
30.0 |
26.2 |
Day 13 |
34.4 |
33.0 |
30.4 |
28.0 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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