Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-569-8 | CAS number: 122-72-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from publication
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Fragrance raw materials monographs: PHENYLPROPYL ACETATE
- Author:
- D.L.J. Opdyke
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology Volume 12, Issues 7–8, December 1974, Pages 965-966
- Reference Type:
- publication
- Title:
- A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients
- Author:
- The RIFM Expert Panel - D. Belsito, D. Bickers, M. Bruze, P. Calow, M.L. Dagli, A.D. Fryer,H. Greim, Y. Miyachi, J.H. Saurat, I.G. Sipes
- Year:
- 2 012
- Bibliographic source:
- Food and Chemical Toxicology 50 (2012) S269–S313
- Reference Type:
- publication
- Title:
- Fragrance material review on 3-phenylpropyl acetate
- Author:
- D. McGinty, C.S. Letizia, A.M. Api
- Year:
- 2 012
- Bibliographic source:
- Food and Chemical Toxicology 50 (2012) S457–S461
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Skin irritation study was conducted on the human subjects to evaluate the irritating potential of 3- Phenylpropyl acetate
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3- Phenylpropyl acetate
- IUPAC Name:
- 3- Phenylpropyl acetate
- Reference substance name:
- 3-phenylpropyl acetate
- EC Number:
- 204-569-8
- EC Name:
- 3-phenylpropyl acetate
- Cas Number:
- 122-72-5
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 3-phenylpropyl acetate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): 3- Phenylpropyl acetate- Molecular formula: C11H14O2- Molecular weight: 178.23 g/mol- Substance type: Organic- Physical state: Liquid- Smiles: c1(CCCOC(C)=O)ccccc1-InChI: 1S/C11H14O2/c1-10(12)13-9-5-8-11-6-3-2-4-7-11/h2-4,6-7H,5,8-9H2,1H3
Constituent 1
Constituent 2
Test animals
- Species:
- human
- Strain:
- other: not applicable
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- other: Petrolatum
- Controls:
- not specified
- Amount / concentration applied:
- 8%
- Duration of treatment / exposure:
- 48 hours
- Observation period:
- 48 hours after application
- Number of animals:
- 5 adult patients
- Details on study design:
- In preliminary study to a maximization test, an 8% concentration of 3-phenylpropyl acetate was applied under occlusion for48 h to five adult patients.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 hours
- Reversibility:
- no data
- Remarks on result:
- other: Non-irritating
- Irritant / corrosive response data:
- none of the adult patient showed skin irritation effects.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- The test chemical 3- Phenylpropyl acetate (CAS No: 122-72-5) was considered to be non-irritating to the skin of 5 adult human patients.
- Executive summary:
Skin irritation study was conducted on 5 adult human patients to evaluate the irritating potential of the 3- Phenylpropyl acetate (CAS No: 122-72-5)as a preliminary study to a maximization test,.
The test material was tested at 8% in petrolatum for 48 hours as a closed patch and observations were made.
On the basis of observations made, 3-Phenylpropyl acetate (CAS No: 122-72-5) was considered as non-irritating to the skin of humans.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
