Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 238-050-2 | CAS number: 14199-15-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Gene mutation of the targetMethyl (4-hydroxyphenyl)acetatewas estimated by using the following predictors: Derek Nexus, Sarah Nexus, Vega (four models).
The predictors were employed in order to apply a weight of evidence (WoE) approach to enhance the reliability of the prediction. In the weight of evidence assessment only reliable predictions are to be taken into account.
Vega models predicted the target compound as non-mutagenic (low reliable - CAESAR), non-mutagenic (low reliable - SarPy/IRFMN), non-mutagenic (not reliable - ISS) and mutagenic (moderate reliable - KNN/Read-Across).
Derek Nexus predicted the chromosome damage in vitro as PLAUSIBLE and the mutagenicity in vitro as INACTIVE.
Sarah Nexus predicted the target compound as negative.
Therefore, it was concluded that Methyl (4-hydroxyphenyl)acetate was predicted as positive for chromosome damage in vitro and as negative for mutagenicity in vitro.
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
