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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1998
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1998
Report date:
1998

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
yes
Test type:
acute toxic class method
Limit test:
yes

Test material

Constituent 1

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: sesame oil DAB 10
Details on oral exposure:
gavage to fasted animals
Doses:
2000 mg/kg body weight
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
No mortalities
Clinical signs:
other: No clinical signs
Gross pathology:
No macroscopical effects

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The registration substance is of low acute oral toxicity.
Executive summary:

The registration substance was investigated for its acute oral toxicity in rats according to the OECD Guideline 401. Five male and five female were administered with the registration substance at dose of 2000 mg/kg. No effect was found. The registration substance is of low acute oral toxicity.