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EC number: 230-291-1 | CAS number: 7011-83-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-08-06 and 2015-10-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 1.25, 2.50, 5.00, 10.0, 20.0 mg/L and control
- Sampling method: At the start of the exposure intervals (0 and 24 hours), sampling was carried out after preparation of the test concentrations. At the end of the exposure intervals (24 and 48 hours), samples were taken directly from the test vessels.
- Sample storage conditions before analysis: at room temperature - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method:A stock solution of 20.0 mg/L of the test item was prepared one day before the start of each exposure interval (at -24 and 0 hours). For this purpose, 44.0 µL of the test item (density of the test item taken into account) were directly introduced by pipette into a 2 L glass flask, completely filled with the dilution water (approximately 2065 mL of ISO test water as specified below) below the water surface while stirring.
- Controls: Dilution water without test item tested under the same conditions as the test groups - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain: Daphnia magna STRAUS
- Age at study initiation: 2 to 24 hours old
- Method of breeding: In glass vessels (2 - 3 L capacity) with approximately 1.8 L culture medium, at 20 ± 2°C, in an incubator, 16 h illumination, light intensity of max. 20 µE * mE-2 * sE-1
- Feeding during test: no
ACCLIMATION
- Acclimation period: 2 hours
- Acclimation conditions: same as test (in dilution water) - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- none
- Test temperature:
- target: 18-22°C, constant within +/- 1°C
- pH:
- - Start of exposure interval (0 hours): 7.87 (control), 7.74-7.83 (test item)
- Start of exposure interval (24 hours): 7.85 (control), 7.71-7.81 (test item)
- End of exposure interval (24 hours): 7.39-7.55 (control), 7.41-7.99 (test item)
- End of exposure interval (48 hours): 7.57-7.66 (control), 7.24-7.66 (test item) - Dissolved oxygen:
- - Start of exposure interval (0 hours): 9.10 (control), 8.12-8.98 (test item)
- Start of exposure interval (24 hours): 9.15 (control), 8.22-8.98 (test item)
- End of exposure interval (24 hours): 8.07-8.32 (control), 6.18-8.43 (test item)
- End of exposure interval (48 hours): 8.26-8.68 (control), 7.04-8.46 (test item) - Salinity:
- not applicable
- Nominal and measured concentrations:
- nominal: 1.25, 2.50, 5.00, 10.0, 20.0 mg/L
measured (start of exposure interval): 1.06, 2.11, 3.77, 7.37, 16.1 mg/L (0 hours); 1.20, 2.39, 4.19, 8.71, 17.0 mg/L (24 hours)
measured (end of exposure interval): 0.860, 1.90, 3.87, 7.21, 14.2 mg/L (24 hours); 1.05, 2.07, 4.31, 7.94, 15.6 mg/L (48 hours) - Details on test conditions:
- TEST SYSTEM
- Test vessel: Sealed glass flasks
- Type: closed (with screw caps made from polypropylene)
- size, headspace, fill volume: 4.5 (ID) x 9.5 (H) cm, without headspace, 130 mL test volume
- Renewal rate of test solution (frequency): daily
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- ISO Test water, according to OECD 202,
- Culture medium different from test medium: Elendt M4, according to Elendt (1990), modified to a total hardness of 160 to 180 mg CaC03/L, is used as culture medium.
- Intervals of water quality measurement: at the start of exposure intervals (0 and 24 hours) and at the end of the exposure intervals (24 and 48 hours)
OTHER TEST CONDITIONS
- Photoperiod: 16/8 h light/dark cycle (target)
- Light intensity: max. 20 µE x mE-2 x sE-1 (1340 lx) (target)
EFFECT PARAMETERS MEASURED:
- Determination of immobilisation after 24 and 48 hours
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2
- Range finding study
- Test concentrations: 1.00, 10.0, 100 mg/L
- Results used to determine the conditions for the definitive study: The following immobilisation rates (%) were determined at 1.00, 10.0 and 100.0 mg/L after 24 h exposure: 0%, 20% and 100%, respectively. After an expsoure period of 48 hours, 0%, 80% and 100% immobilisation was observed for 1.00, 10.0 and 100.0 mg/L, respectively. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC10
- Effect conc.:
- 1.04 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95%CL: < 1.04 - 1.94
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2.98 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL: 2.50-3.61
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 7.79 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.04 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 2.11 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC10
- Effect conc.:
- 1.68 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL: < 1.04-3.07
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 5.59 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL: 3.43-9.95
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 15.7 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- All test concentrations were visually clear throughout the exposure period.
- Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- The EC50 value determined after 24 hours for the most recent of the monthly performed reference tests was 2.00 mg/L (CL: 1.83 - 2.19 mg/L). - Reported statistics and error estimates:
- EC10- and EC50-values (after 24 and 48 hours) were calculated by sigmoidal dose-response regression. The respective 95 % confidence limits were calculated from the standard error and the t-distribution. No mathematical calculation was performed for the EC100 values (after 24 and 48 hours) and for the NOEC and LOEC (after 48 hours).
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a 48 h semi-static toxicity test with Daphnia magna the EC50 value based on mobility of the test substance was found to be 2.98 mg/L.
- Executive summary:
In the acute immobilisation test with Daphnia magna (STRAUS), the effects of the test item were determined according to OECD 202 (2004). The study was conducted in a closed system (sealed glass flasks) without headspace under static conditions over a period of 48 h with the following concentrations: 1.25 - 2.50 - 5.00 - 10.0 - 20.0 mg/L (nominal). Twenty daphnids were exposed to each concentration level and the control. The concentrations of the test item were analytically verified via GC-MS at the start (0 and 24 hours) and at the end of the exposure intervals (24 and 48 hours) in all concentration levels and the control. Since the measured test item concentrations did not remain within +/- 20% of the nominal concentrations, the effect values based on the geometric mean measured concentrations of the test item calculated as follows: 1.04, 2.11, 4.03, 7.79 and 15.7 mg/L. Based on the geometric mean measured concentrations of the test item, the 48 -hour EC50 for Daphnia magna was 2.98 mg/L (95% CL: 2.50 - 3.61 mg/L). The NOEC after 48 hours was 1.04 mg/L. The LOEC after 48 hours was 2.11 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to attached "Read-across justification".
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2.98 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL: 2.50-3.61
Referenceopen allclose all
Immobilisation Rates after 24 and 48 h of Exposure in the Definitive Test
(n = 20, divided into 4 replicates with 5 daphnids each)
Test substance |
Immobilisation [%] |
||||||||||
nominal concentration [mg/L] |
Geometric mean measured concentration [mg/L] |
24 h |
48 h |
||||||||
Replicates |
Replicates |
||||||||||
1 |
2 |
3 |
4 |
MV |
1 |
2 |
3 |
4 |
MV |
||
20 |
15.7 |
80 |
60 |
100 |
80 |
80 |
100 |
100 |
100 |
100 |
100 |
10 |
7.79 |
40 |
100 |
40 |
60 |
60 |
100 |
100 |
100 |
100 |
100 |
5 |
4.03 |
40 |
80 |
0 |
40 |
40 |
60 |
80 |
60 |
100 |
75 |
2.5 |
2.11 |
20 |
0 |
0 |
40 |
15 |
40 |
0 |
0 |
60 |
25 |
1.25 |
1.04 |
0 |
0 |
0 |
0 |
0 |
20 |
20 |
0 |
0 |
10 |
Control |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Measured Concentrations and Percent of the Nominal Concentrations of the Test Item during the Definitive Test
Sampling date |
2015-08-12 0 hours Start of the exposure interval |
2015-08-13 24 hours End of the exposure interval |
2015-08-13 24 hours Start of the exposure interval |
2015-08-14 48 hours End of the exposure interval |
||||||
Nominal test item concentration [mg/L] |
Test substance |
Geometric mean |
||||||||
|
Meas. conc. [mg/L] |
% |
Meas. conc. [mg/L] |
% |
Meas. conc. [mg/L] |
% |
Meas. conc. [mg/L] |
% |
Meas. conc. [mg/L] |
% |
20 |
16.1 |
81 |
14.2 |
71 |
17 |
85 |
15.6 |
78 |
15.7 |
79 |
10 |
7.37* |
74 |
7.21 |
72 |
8.71 |
87 |
7.94 |
79 |
7.79 |
78 |
5 |
3.77* |
75 |
3.87 |
77 |
4.19 |
84 |
4.31 |
86 |
4.03 |
81 |
2.5 |
2.11 |
84 |
1.9 |
76 |
2.39 |
96 |
2.07 |
83 |
2.11 |
84 |
1.25 |
1.06 |
85 |
0.86 |
69 |
1.2 |
96 |
1.05 |
84 |
1.04 |
83 |
Control |
< LOQ |
< LOQ |
< LOQ |
< LOQ |
Meas. conc. = measured concentration of the test item, preconcentration and dilution factor taken into account
% = percent of the nominal concentration of the test item
LOQ = limit of quantification of the analytical method (0.25 mg/L of the test item)
* = reanalysed, mean value of 3 replicates, dilution factor taken into account
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.98 mg/L
Additional information
For the test substance no short-term toxicity test to aquatic invertebrates are available.
Therefore, an analogy approach to the read-across substance Reaction mass of trans-5 -hexyldihydro-4 -methylfuran-2(3H)-one and cis-5 -hexyldihydro-4 -methylfuran-2(3H)-one is applied.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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