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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 02-29, 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
Test material
- Test material form:
- solid: particulate/powder
- Details on test material:
- Batch No.: UGe-RS Kilo 1
Color: Yellow
Odor: Not specific
Storage conditions: room temperature
Solubility and stability: Very good solubility in water, stable in solution at least 2 days
Expiring date: 12.12.2018
Correction factor: 1.07
Constituent 1
- Specific details on test material used for the study:
- Test Item name Yellow LF 6911
Batch No. UGe-RS Kilo 1
Purity 93.3 % (organic part excluding water and salts not containing similar chromophore)
Expiry date 12 December 2018
Storage room temperature
Study design
- Analytical method:
- liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Key result
- Type:
- Pow
- Partition coefficient:
- 0.008
- Temp.:
- 20 °C
- pH:
- > 7.64 - < 7.91
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.12
- Temp.:
- 20 °C
- pH:
- > 7.64 - < 7.9
- Details on results:
- The partition coefficient (Pow) of Yellow LF 6911 in n-octanol - water was determined to be 0.0080 ± 0.0023 which corresponds to log Pow of -2.12 ± 0.105 (95% confidence interval) using the shake flask method.
Any other information on results incl. tables
Results of the test, the measured concentrations of Yellow LF 6911 in the test vessels and the standard deviations (RSD) are provided in the following table:
Results of the determination of Yellow LF 6911 concentrations
Ratio of solvents |
Measured concentration of Test Item (µg/ml) |
pH |
Measured concentration of Test Item (µg/ml) |
||
In Aqueous phase |
Mean |
In n-octanol phase |
Mean |
||
1:1 |
29.57 |
30.20 |
7.91 |
0.190 |
0.186 |
30.16 |
30.81 |
7.91 |
0.184 |
0.191 |
|
30.40 |
31.00 |
7.91 |
0.216 |
0.217 |
|
Mean |
30.67 |
7.91 |
0.198 |
||
RSD% |
1.4 |
|
8.3 |
||
Measured test item µg |
230.03 |
|
1.486 |
||
Total nominal quantity of test item |
256.83 µg |
||||
Total quantity of test item |
231.5 µg |
Recovery: 90 % |
Results of the determination of Yellow LF 6911 concentrations (continued)
Ratio of solvents |
Measured concentration of Test Item (µg/ml) |
pH |
Measured concentration of Test Item (µg/ml) |
||
In Aqueous phase |
Mean |
In n-octanol phase |
Mean |
||
1:2 |
24.36 |
24.41 |
7.89 |
0.150 |
0.163 |
24.54 |
24.50 |
7.89 |
0.158 |
0.176 |
|
23.63 |
24.12 |
7.89 |
0.161 |
0.156 |
|
Mean |
24.34 |
7.89 |
0.165 |
||
RSD% |
0.8 |
|
6.1 |
||
Measured test item µg |
243.42 |
|
0.825 |
||
Total nominal quantity of test item |
256.83 µg |
||||
Total quantity of test item |
244.2 µg |
Recovery: 95 % |
|||
2:1 |
43.82 |
43.85 |
7.64 |
0.911 |
0.905* |
50.95 |
51.86 |
7.64 |
0.504 |
0.538 |
|
49.47 |
49.38 |
7.64 |
0.672 |
0.680 |
|
Mean |
48.36 |
7.64 |
0.609 |
||
RSD% |
8.5 |
|
16.5 |
||
Measured test item µg |
241.80 |
|
6.09 |
||
Total nominal quantity of test item |
256.83 µg |
||||
Total quantity of test item |
259.2 µg |
Recovery: 101 % |
* sample preparation error, not used for the calculations
The calculated partition coefficient (Pow) and logPoware summarised in the following table:
Partition coefficients measured for Test Item
Ratio of solvents |
Partition coefficient |
Log Pow |
|
Pow |
Mean |
||
1:1 |
0.0062 |
0.0065 |
-2.19 |
0.0062 |
|||
0.0070 |
|||
1:2 |
0.0067 |
0.0068 |
-2.17 |
0.0072 |
|||
0.0065 |
|||
2:1 |
0.0206* |
0.0121 |
-1.92 |
0.0104 |
|||
0.0138 |
|||
Mean all±95% confidence interval |
- |
0.0080±0.0023 |
-2.12±0.105 |
RSD % |
- |
- |
-6 |
* sample preparation error, not used for the calculations
Applicant's summary and conclusion
- Conclusions:
- In conclusion, the partition coefficient (Pow) of Yellow LF 6911 in n-octanol - water was determined to be 0.0080 ± 0.0023 which corresponds to log Pow of -2.12 ± 0.105 (95% confidence interval) using the shake flask method.
- Executive summary:
The purpose of this study was to determine the partition coefficient of Yellow LF 6911.
The experiments were carried out applying volume ratios and quantities of the test substance depending on expected partition and the LOQ of the analytical method in both phases. The maximum concentration in either phase was less than 0.01 mol/L. Three parallel tests were carried out. In the first, the calculated volume ratio was applied, in the second, this ratio was divided by two and in the third, this ratio was multiplied by two.
Table 2. Volume of the phases at the different solvent ratios:
Ratio
n-Octanol (mL)
n-Octanol stock solution (mL)
Ultrapure Water (mL)
1 : 1
4.5
3
7.5
1 : 2
2
3
10
2 : 1
7
3
5
Three parallel tests were carried out at all solvent ratios.
The test vessels were shaken by hand through 180° about its transverse axis a hundred times during five minutes.
The separation of the two phases was achieved by centrifugation at 20°C (4000 rpm). The pH of aqueous phases was measured and the concentrations of the stock solution and both phases were determined.
The n-Octanol samples were diluted with acetonitrile for the measurements. The aqueous samples were diluted with acetonitrile and withacetonitrile-water 50-50 (v/v %) mixturebefore the HPLC analysis. Yellow LF 6911 content was measured in both phases by reverse phase HPLC method.
In conclusion, the partition coefficient (Pow) of Yellow LF 6911 in n-octanol - water was determined to be 0.0080 ± 0.0023 which corresponds to log Pow of -2.12 ± 0.105 (95% confidence interval) using the shake flask method.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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