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EC number: 213-105-3 | CAS number: 924-44-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07-12-1990 to 26-12-1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented GLP study performed according to European guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Glyoxylate d'Ethyle
- IUPAC Name:
- Glyoxylate d'Ethyle
- Reference substance name:
- Ethyl glyoxalate
- IUPAC Name:
- Ethyl glyoxalate
- Reference substance name:
- Ethyl glyoxylate
- EC Number:
- 213-105-3
- EC Name:
- Ethyl glyoxylate
- Cas Number:
- 924-44-7
- Molecular formula:
- C4 H6 O3
- IUPAC Name:
- ethyl glyoxylate
- Test material form:
- other: viscous liquid
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa Crédo (69210 L'Arbresle, France)
- Age at study initiation: 5-6 weeks
- Weight at study initiation: 169 ± 7 g (males) and 150 ± 4 g (females)
- Fasting period before study: yes (18 hours before the administration of the substance). Food was given 4 hours after the treatment.
- Housing: groups of 5 animals of the same sex, in polycarbonate cages (48 x 27 x 20 cm)
- Diet: certified pellet diet "Rats-Mice sustenance ref. A04C", ad libitum
- Water: free access to tap water filtered by 0.22 micron filter membrane
- Acclimation period: at least 5 days and they were observed daily
ENVIRONMENTAL CONDITIONS
- Temperature: 22 ± 3 °C
- Humidity: 50 ± 20 % relative humidity
- Air changes: non recycled, filtered by absolute filters
- Photoperiod: 12 hrs dark / 12 hrs light
IN-LIFE DATES: from 12 December 1990 to 26 Decembre 1990 (from treatment to the end of the observation period)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- paraffin oil
- Details on oral exposure:
- The test substance was administered suspended in paraffin oil at a dose level of 2000 mg/kg at a volume of 10 ml/kg.
- Doses:
- Single dose of 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
clinical signs: frequently after administration and at least once a day for 14 days.
Mortality: frequently after administration and at least twice a day for 14 days.
Body weight: just before administration, and then on days 5, 8 and 15. The body weight gain of the treated animals was compared to a reference curve of the CIT control animals with the same initial weight
- Necropsy of survivors performed: yes with the macroscopic examination of the main organs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occured during the observation period at the tested dose of 2000 mg/kgbw
- Clinical signs:
- Hypokinesia was observed in 2 males and in one female 15 min. after administration of the test substance and in all animals after one hour and for 3 hours. No further clinical signs were noted in the animals after 24 hours and until the end of the study.
- Body weight:
- The body weight gain of the animal was normal.
- Gross pathology:
- The macroscopic examination of the main organs of the animals sacrified at the end of the study revealed no apparent abnormality. Due to the absence of macroscopic lesions, no samples were taken for histological examinations.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of Glyoxalate d'Ethyle (HF 7846) was higher than 2000 mg/kg bw (no mortality at this single tested dose).
- Executive summary:
Glyoxalate d'Ethyle (HF 7846) was tested for acute oral toxicity in male and female Sprague-Dawley rats by gavage according to EU testing guideline B.1 and Good Laboratory Practices.
No mortality was observed at 2000 mg/kg bw in this limit acute oral toxicity test. The LD50 of Glyoxalate d'Ethyle (HF 7846) was higher than 2000 mg/kg bw.
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