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Diss Factsheets
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EC number: 257-789-1 | CAS number: 52256-37-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: screening test, other
- Remarks:
- BOD5/COD
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- the complete read across justification is detailed in section 13, source study has reliability 2.
- Principles of method if other than guideline:
- The 5-day Biological Oxygen Demand (BOD5) was measured at 10 g/l (at 5, 10, 20 or 25 ml/500 ml).
The Chemical Oxygen Demand (COD) was measured by titration. - GLP compliance:
- no
- Oxygen conditions:
- not specified
- Inoculum or test system:
- not specified
- Details on inoculum:
- no data
- Duration of test (contact time):
- 5 d
- Details on study design:
- no data
- Preliminary study:
- no data
- Test performance:
- no data
- Remarks on result:
- other: BOD5/COD
- Details on results:
- none
- Parameter:
- BOD5
- Value:
- 27 mg O2/g test mat.
- Parameter:
- COD
- Value:
- 1 021 mg O2/g test mat.
- Results with reference substance:
- no data
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Under the test conditions, the substance showed low biodegradation potential.
- Executive summary:
Method
The study was conducted to evaluate the biodegradation potential of the test substance (at ca. 75 % purity) via BOD5 and COD determination.
Results
The ratio of these values was equivalent to 0.03, suggesting low biodegradation potential of the substance under the test conditions.
- Endpoint:
- biodegradation in water: ready biodegradability
- Remarks:
- prediction
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- QSAR estimation
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- QSAR dyes R&C report produced by version QSAR dyes RC 2.0 Developed by Milano Chemometrics and QASR research group Dept. Earth and Environmental Science, University Milano
Bicocca, Italy. - Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Validity criteria fulfilled:
- not applicable
- Remarks:
- estimation by prediction tool
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Based on prediction carried out with the prediction tool, the substance resulted as non ready biodegradable.
- Executive summary:
Results
The substance was predicted to be not ready biodegradable.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- other: expert judgement based on available data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Guideline:
- other: REACH Guidance on QSARs R.6
- Inoculum or test system:
- other: expert judgement
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Validity criteria fulfilled:
- not applicable
- Remarks:
- Expert judgement and estimation by QSAR dyes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Based on prediction carried out with QSAR dyes, the substance resulted as non ready biodegradable.
- Executive summary:
Method
Estimate of probability of rapid biodegradation relying on QSAR dyes. The overall assessment is based on the responses given by different predictive models for biodegradability under various conditions: linear and non-linear models, ultimate and primary survey models, MITI linear and non-linear models, anaerobic linear model.
Results
The substance was predicted to be not ready biodegradable.
Referenceopen allclose all
% BOD5/COD = 3
Description of key information
The substance is considered as not readily biodegradable based QSAR prediction and expert judgemenet
Key value for chemical safety assessment
Additional information
No information is available on the substance itself, thus the assessment relied on a read across approach. Solvent Orange 062 and Similar Substance 01 are chromium complexes with 2 ligands. In both cases, the 2 ligands have the same chemical structure, i.e. a phenyl ring connected via diazo bond to a phenyl pyrazole. These ligands show minor differences in the position of substituents, i.e. hydroxy and nitro gorups, as well as in the presence of a sulfonate group in Similar Substance 01.
Due to the lack of data from ready biodegradability tests, data on BOD5/COD ratio of Simialr Substance 01 was used for the assessement. No evidence of rapid degradation was found in the available study, where a BOD5/COD = 3 % was found.
Moreover, Solvent Orange 062 was predicted to be non ready biodegradable by QSAR dyes prediction tool.
On these bases, Solvent Orange 062 was considered as non rapidly degradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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