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EC number: 202-722-3 | CAS number: 99-03-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Acute Toxicity
- Author:
- German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety and the Environmental Ministries of all 16 Federal States of Germany (Länder)
- Year:
- 1 996
- Bibliographic source:
- GSBL – Joint Substance Data Pool of the German Federal Government and the German Federal States; GSBL Datenlieferung Sommer 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as per mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity performed on rat by using test chemical 3'-aminoacetophenone
- GLP compliance:
- no
Test material
- Reference substance name:
- 3'-aminoacetophenone
- EC Number:
- 202-722-3
- EC Name:
- 3'-aminoacetophenone
- Cas Number:
- 99-03-6
- Molecular formula:
- C8H9NO
- IUPAC Name:
- 1-(3-aminophenyl)ethan-1-one
- Details on test material:
- - Name of test material: 3’-aminoacetophenone
- Molecular formula: C8H9NO
- Molecular weight: 135.16 g/mol
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Source: No data
Age at study initiation: No data
Weight at study initiation: 90 -120 g
Fasting period before study: Not fasted
Housing: No data
Diet (e.g. ad libitum): No data
Water (e.g. ad libitum): No data
Acclimation period: No data
ENVIRONMENTAL CONDITIONS
Temperature (°C): No data
Humidity (%):No data
Air changes (per hr): No data
Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: From: No data To: No data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: It was necessary to bring the volume administered per rat in 1ml to 10 ml, the substance was dissolved in water, corn oil or 1% Tergitol 7 Penetrant (an aqueous solution of 25% 3 Sodium,9diethyl6tridecanolsulfat)
- Details on oral exposure:
- VEHICLE
Concentration in vehicle: It was necessary to bring the volume administered per rat in 1ml to 10 ml
Amount of vehicle (if gavage): 1 -10 ml
Justification for choice of vehicle: No data
Lot/batch no. (if required): No data
Purity: No data
MAXIMUM DOSE VOLUME APPLIED:
No data - Doses:
- Doses differed in logarithmic sequence by a factor of 2. The substance was given as a single dose by gavage.
- No. of animals per sex per dose:
- 5 males/ dose
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 14 days (or other?) : 14 days
- Statistics:
- Based on the occurring during this time
Mortalities were statistically the most likely
LD50 value and the confidence level by the method of Thompson using the Tables of Weil determined.
Results and discussion
- Preliminary study:
- no data
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 870 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Mortality
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- For the study 90- 120g male Carworth Wistar rats, were used. Each dose group contained 5 rats. Doses differed in logarithmic sequence by a factor of 2. The substance was given as a single dose by gavage. The animals had not previously fasted. A total of 157 substances were investigated. The work does not contain information about which substances and which were tested undiluted in dissolved or suspended form.
Based on the occurring during this time, Mortalities were statistically the most likely LD50 value and the confidence level by the method of Thompson using the Tables of Weil determined.
The acute oral LD50 value for 3’-aminoacetophenone in rats is 1870mg/kg - Executive summary:
For the study 90- 120g male Carworth Wistar rats, were used. Each dose group contained 5 rats. Doses differed in logarithmic sequence by a factor of 2. The substance was given as a single dose by gavage. The animals had not previously fasted. A total of 157 substances were investigated. The work does not contain information about which substances and which were tested undiluted in dissolved or suspended form.
It was necessary to bring the volume administered per rat in 1ml to 10 ml, the substance was dissolved in water, corn oil or 1% Tergitol 7 Penetrant (an aqueous solution of 25% 3 Sodium,9diethyl6tridecanolsulfat)
After administration of the test chemical the rats were observed for 14 days.
Based on the occurring during this time, Mortalities were statistically the most likely LD50 value and the confidence level by the method of Thompson using the Tables of Weil determined.
The acute oral LD50 value for 3’-aminoacetophenone in rats is 1870mg/kg
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