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EC number: 200-665-9 | CAS number: 67-71-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from handbook.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Acute dermal toxicity study of test chemical in rodents.
- Author:
- Richard J. Lewis
- Year:
- 2 012
- Bibliographic source:
- Sax's Dangerous Properties of Industrial Materials
- Reference Type:
- review article or handbook
- Title:
- Acute Toxicity - TEST SUBSTANCE
- Author:
- John Wiley & Sons
- Year:
- 2 005
- Bibliographic source:
- Patty's Industrial Hygiene and Toxicology
- Reference Type:
- other: authoritative database
- Title:
- Acute Dermal toxicity - Test chemical
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- ChemIDplus
- Reference Type:
- other: Authoritative database
- Title:
- Toxicity of test chemical
- Author:
- IFA GESTIS
- Year:
- 2 018
- Bibliographic source:
- GESTIS Substance Database
- Reference Type:
- secondary source
- Title:
- Acute dermal toxicity study of test chemical in rabbits
- Author:
- NTRL
- Year:
- 1 991
- Bibliographic source:
- NTRL report
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- The toxicity study was examined to evaluate the acute toxic effects of administration of the test chemical in male New Zealand White rabbits by the dermal route.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl sulphone
- EC Number:
- 200-665-9
- EC Name:
- Dimethyl sulphone
- Cas Number:
- 67-71-0
- Molecular formula:
- C2H6O2S
- IUPAC Name:
- dimethyl sulphone
- Details on test material:
- - IUPAC Name: Dimethyl sulphone
- InChI: 1S/C2H6O2S/c1-5(2,3)4/h1-2H3
- Smiles: S(C)(C)(=O)=O
- Molecular formula :C2H6O2S
- Molecular weight :94.1334 g/mole
- Substance type:Organic
- Physical state:Solid, crystalline white odorless
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Skippack Farms
- Weight at study initiation: mean wt: 2.23
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- physiological saline
- Details on dermal exposure:
- TEST SITE
- Area of exposure: The closely clipped skin.
- Type of wrap if used: The test chemical was held under an impervious cuff.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The cuffs were removed and the application sites were gently wiped to remove the test substance.
- Time after start of exposure:24-hr
TEST MATERIAL
- For solids, paste formed: yes, the test substance, prepared as a paste in saline (1:1) - Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- Total = 2
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: Animals were observed for mortality and clinical signs.
- Necropsy of survivors performed: yes - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed at the dose concentration of 5000 mg/kg bw.
- Clinical signs:
- other: Well defined erythema and very slight edema was observed.
- Gross pathology:
- No gross changes were observed in either rabbit.
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute dermal LD50 value was considered to be >5000 mg/kg bw, when 2 male New Zealand White rabbits were treated with the given test chemical by dermal application occlusively.
- Executive summary:
The acute dermal toxicity study was conducted by using the given test chemical in 2 male New Zealand White rabbits at the dose concentration of 5000 mg/kg bw.
The test substance, prepared as a paste in saline (1:1), was held under an impervious cuff in continuous 24 hr contact with the closely clipped skin. After the 24-hr exposure, the cuffs were removed and the application sites were gently wiped to remove the test substance. Animals were observed for mortality and clinical signs. Necropsy of survivors performed.
No mortality was observed at the dose concentration of 5000 mg/kg bw. Well defined erythema and very slight edema was observed. No gross changes were observed in either rabbit.
Hence, the LD50 value was considered to be >5000 mg/kg bw, when 2 male New Zealand White rabbits were treated with the given test chemical by dermal application occlusively.
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