Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 223-798-4 | CAS number: 4078-19-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April to May 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented, scientifically acceptable study report
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- β-methylaziridine-1-propiononitrile
- EC Number:
- 223-798-4
- EC Name:
- β-methylaziridine-1-propiononitrile
- Cas Number:
- 4078-19-7
- Molecular formula:
- C6H10N2
- IUPAC Name:
- 3-(aziridin-1-yl)butanenitrile
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean body weight: males 198 g, females 168 g
The animals were offered a standardized animal laboratory diet (Herilan MRH).
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- olive oil
- Details on dermal exposure:
- The test concentrations used were 15, 25, 45 and 50 % (G/G).
Application area: ca. 50 cm2
Application site: back - Duration of exposure:
- 24 hours
- Doses:
- 100, 200, 400, 681 and 1000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical and local signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 300 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 100 mg/kg bw: no deaths after 14 days; 200 mg/kg bw: 3/6 after 14 days (only males died, starting after 7 days); 400 mg/kg bw: 2/6 after 14 days (1 male after 48 h and 1 female after 7 days); 681 and 1000 mg/kg bw: 6/6 after 14 days (starting after 24 h)
- Clinical signs:
- other: Dyspnea, apathy, excitation, staggering, twitching, spastic gait, flexion convulsions, biting convulsions, diarrhea, anemic paleness, exsiccosis, salivation, poor general state, ruffled fur, breathlessness, clotty eyes, leath deaths.
- Gross pathology:
- Animals that died: heart: acute dilatation (right); liver: manifold slight brightened; kidneys; isolated yellow-white, radiate striation in the papilla region (papilla necrosis); animals manifold severe emaciated.
Sacrificed animals: kidneys: distinct papilla necrosis. - Other findings:
- Local findings:
1000 mg/kg bw: After 24 hours questionable reddening, slight edema.
681 mg/kg bw: After 24 hours questionable reddening, slight edema.
400 mg/kg bw: After 24 hours questionable reddening, slight edema. After 7 days slight scaling (males only), otherwise without findings.
200 mg/kg bw: After 24 hours questionable reddening, slight edema; after 6 hours: slight scaling, very slight up to slight edema; after 14 days without findings.
100 mg/kg bw: After 24 hours questionable reddening, slight edema; after 7 days without findings.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information
- Conclusions:
- The acute dermal LD 50 was around 300 mg(kg bw for male and female rats.
- Executive summary:
The application of the test substance onto the back of female and male rats in doses of 100, 200, 400, 681 and 1000 mg/kg bw. Lead to deaths and different clinical signs in the animals. The acute dermal LD50 was determined to be around 300 mg/kg bw for male and female rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.