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EC number: 245-821-7 | CAS number: 23680-84-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation:
The dermal irritation potential of 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) was estimated using OECD QSAR toolbox version 3.4 with logPow as the primary descriptor. The substance 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) was estimated to be not irritating to the skin of New Zealand White rabbits. Based on the estimated result 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) can be considered to be not irritating to skin and can be classified under the category ˋ Not Classified’ as per CLP regulation.
Eye irritation:
The ocular irritation potential of 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) was estimated using OECD QSAR toolbox version 3.4 with logPow as the primary descriptor. The substance 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) was estimated to be not irritating into the eyes of New Zealand White rabbits. Based on the estimated result 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) can be considered to be not irritating to eye and can be classified under the category ˋ Not Classified’ as per CLP regulation.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is from OECD QSAR toolbox version 3.4 and QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.4
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material : 2-chloro-6,7-dimethoxyquinazolin-4-amine
- Molecular formula : C10H10ClN3O2
- Molecular weight : 239.661 g/mol
- Smiles notation : n1c(c2cc(OC)c(cc2nc1Cl)OC)N
- InChl : 1S/C10H10ClN3O2/c1-15-7-3-5-6(4-8(7)16-2)13-10(11)14-9(5)12/h3-4H,1-2H3,(H2,12,13,14)
- Substance type: Organic
- Physical state: Solid - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- No data available
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No data available
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3
- Details on study design:
- No data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No skin irritation was observed in treated rabbits.
- Interpretation of results:
- other: not irritating
- Conclusions:
- The substance 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) was estimated to be not irritating to the skin of New Zealand White rabbits. Based on the estimated result 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) can be considered to be not irritating to skin.
- Executive summary:
The dermal irritation potential of 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) was estimated using OECD QSAR toolbox version 3.4 with logPow as the primary descriptor. The substance 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) was estimated to be not irritating to the skin of New Zealand White rabbits. Based on the estimated result 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) can be considered to be not irritating to skin and can be classified under the category ˋ Not Classified’ as per CLP regulation.
Reference
Estimation
method: Takes mode value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
((((((("a"
or "b" or "c" or "d" )
and "e" )
and "f" )
and "g" )
and "h" )
and ("i"
and (
not "j")
)
)
and ("k"
and "l" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Non-covalent interaction AND
Non-covalent interaction >> DNA intercalation AND Non-covalent
interaction >> DNA intercalation >> Fused-Ring Primary Aromatic Amines
AND Radical AND Radical >> Radical mechanism via ROS formation
(indirect) AND Radical >> Radical mechanism via ROS formation (indirect)
>> Fused-Ring Primary Aromatic Amines AND SN1 AND SN1 >> Nucleophilic
attack after metabolic nitrenium ion formation AND SN1 >> Nucleophilic
attack after metabolic nitrenium ion formation >> Fused-Ring Primary
Aromatic Amines by DNA binding by OASIS v.1.4
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as AN2 AND AN2 >> Nucleophilic
addition to pyridonimine tautomer of aminopyridoindoles or
aminopyridoimidazoles (hypothesized) AND AN2 >> Nucleophilic addition to
pyridonimine tautomer of aminopyridoindoles or aminopyridoimidazoles
(hypothesized) >> Heterocyclic Aromatic Amines AND Radical reactions AND
Radical reactions >> ROS generation and direct attack of hydroxyl
radical to the C8 position of nucleoside base AND Radical reactions >>
ROS generation and direct attack of hydroxyl radical to the C8 position
of nucleoside base >> Heterocyclic Aromatic Amines AND SE reaction
(CYP450-activated heterocyclic amines) AND SE reaction (CYP450-activated
heterocyclic amines) >> Direct attack of arylnitrenium cation to the C8
position of nucleoside base AND SE reaction (CYP450-activated
heterocyclic amines) >> Direct attack of arylnitrenium cation to the C8
position of nucleoside base >> Heterocyclic Aromatic Amines AND SNAr
AND SNAr >> Nucleophilic aromatic substitution on activated aryl and
heteroaryl compounds AND SNAr >> Nucleophilic aromatic substitution on
activated aryl and heteroaryl compounds >> Activated aryl and heteroaryl
compounds AND SR reaction (peroxidase-activated heterocyclic amines) AND
SR reaction (peroxidase-activated heterocyclic amines) >> Direct attack
of arylnitrenium radical to the C8 position of nucleoside base AND SR
reaction (peroxidase-activated heterocyclic amines) >> Direct attack of
arylnitrenium radical to the C8 position of nucleoside base >>
Heterocyclic Aromatic Amines by Protein binding by OASIS v1.4
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as SNAr AND SNAr >> Nucleophilic
aromatic substitution AND SNAr >> Nucleophilic aromatic substitution >>
Halo-pyrimidines by Protein binding by OECD
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Anilines (Unhindered) by Aquatic
toxicity classification by ECOSAR
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OECD ONLY
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as No superfragment by
Superfragments ONLY
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as High (Class III) by Toxic hazard
classification by Cramer (extension) ONLY
Domain
logical expression index: "h"
Similarity
boundary:Target:
COc1cc2c(cc1OC)c(N)nc(Cl)n2
Threshold=20%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] AND
Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Aromatic Carbon
[C] AND Aromatic Nitrogen AND Chlorine, aromatic attach [-Cl] AND
Chlorine, olefinic attach [-Cl] AND Olefinic carbon [=CH- or =C<] AND
Oxygen, one aromatic attach [-O-] by Organic functional groups (US EPA)
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Bromine, olefinic attach [-Br]
by Organic functional groups (US EPA)
Domain
logical expression index: "k"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -0.263
Domain
logical expression index: "l"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 2.56
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is from OECD QSAR toolbox version 3.4 and QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.4
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - IUPAC Name: 2-Chloro-6,7-dimethoxyquinazolin-4-amine
- Mol. formula: C10H10ClN3O2
- Molecular Weight: 239.661 g/mole
- Smiles: n1c(c2cc(OC)c(cc2nc1Cl)OC)N
- InChI: 1S/C10H10ClN3O2/c1-15-7-3-5-6(4-8(7)16-2)13-10(11)14-9(5)12/h3-4H,1-2H3,(H2,12,13,14)
- Physical state: Solid - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- No data available
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No data available
- Duration of treatment / exposure:
- single application
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- No data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No known signs of ocular lesions were observed.
- Interpretation of results:
- other: not irritating
- Conclusions:
- The substance 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) was estimated to be not irritating into the eyes of New Zealand White rabbits. Based on the estimated result 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) can be considered to be not irritating to eye.
- Executive summary:
The ocular irritation potential of 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) was estimated using OECD QSAR toolbox version 3.4 with logPow as the primary descriptor. The substance 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) was estimated to be not irritating into the eyes of New Zealand White rabbits. Based on the estimated result 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) can be considered to be not irritating to eye and can be classified under the category ˋ Not Classified’ as per CLP regulation.
Reference
Estimation
method: Takes mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(((("a"
or "b" or "c" or "d" )
and ("e"
and (
not "f")
)
)
and ("g"
and (
not "h")
)
)
and ("i"
and "j" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Non-covalent interaction AND
Non-covalent interaction >> DNA intercalation AND Non-covalent
interaction >> DNA intercalation >> Fused-Ring Primary Aromatic Amines
AND Radical AND Radical >> Radical mechanism via ROS formation
(indirect) AND Radical >> Radical mechanism via ROS formation (indirect)
>> Fused-Ring Primary Aromatic Amines AND SN1 AND SN1 >> Nucleophilic
attack after metabolic nitrenium ion formation AND SN1 >> Nucleophilic
attack after metabolic nitrenium ion formation >> Fused-Ring Primary
Aromatic Amines by DNA binding by OASIS v.1.4
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as AN2 AND AN2 >> Nucleophilic
addition to pyridonimine tautomer of aminopyridoindoles or
aminopyridoimidazoles (hypothesized) AND AN2 >> Nucleophilic addition to
pyridonimine tautomer of aminopyridoindoles or aminopyridoimidazoles
(hypothesized) >> Heterocyclic Aromatic Amines AND Radical reactions AND
Radical reactions >> ROS generation and direct attack of hydroxyl
radical to the C8 position of nucleoside base AND Radical reactions >>
ROS generation and direct attack of hydroxyl radical to the C8 position
of nucleoside base >> Heterocyclic Aromatic Amines AND SE reaction
(CYP450-activated heterocyclic amines) AND SE reaction (CYP450-activated
heterocyclic amines) >> Direct attack of arylnitrenium cation to the C8
position of nucleoside base AND SE reaction (CYP450-activated
heterocyclic amines) >> Direct attack of arylnitrenium cation to the C8
position of nucleoside base >> Heterocyclic Aromatic Amines AND SNAr
AND SNAr >> Nucleophilic aromatic substitution on activated aryl and
heteroaryl compounds AND SNAr >> Nucleophilic aromatic substitution on
activated aryl and heteroaryl compounds >> Activated aryl and heteroaryl
compounds AND SR reaction (peroxidase-activated heterocyclic amines) AND
SR reaction (peroxidase-activated heterocyclic amines) >> Direct attack
of arylnitrenium radical to the C8 position of nucleoside base AND SR
reaction (peroxidase-activated heterocyclic amines) >> Direct attack of
arylnitrenium radical to the C8 position of nucleoside base >>
Heterocyclic Aromatic Amines by Protein binding by OASIS v1.4
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as SNAr AND SNAr >> Nucleophilic
aromatic substitution AND SNAr >> Nucleophilic aromatic substitution >>
Halo-pyrimidines by Protein binding by OECD
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Anilines (Unhindered) by Aquatic
toxicity classification by ECOSAR
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as SNAr AND SNAr >> Nucleophilic
aromatic substitution AND SNAr >> Nucleophilic aromatic substitution >>
Halo-pyrimidines by Protein binding by OECD
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Acylation OR Acylation >> Direct
Acylation Involving a Leaving group OR Acylation >> Direct Acylation
Involving a Leaving group >> Acetates OR No alert found OR SN2 OR SN2 >>
SN2 reaction at sp3 carbon atom OR SN2 >> SN2 reaction at sp3 carbon
atom >> Allyl acetates and related chemicals OR SNAr >> Nucleophilic
aromatic substitution >> Activated halo-benzenes OR SNAr >> Nucleophilic
aromatic substitution >> Activated halo-pyridines OR SNAr >>
Nucleophilic aromatic substitution >> Halo-triazines by Protein binding
by OECD
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Not known precedent reproductive
and developmental toxic potential by DART scheme v.1.0
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Metal atoms were identified OR
Not covered by current version of the decision tree by DART scheme v.1.0
Domain
logical expression index: "i"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 0.295
Domain
logical expression index: "j"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 5.46
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
Various studieshas been investigated for the test chemical2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4)to observe the potential for dermal irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits for target chemical2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) and its structurally similar read across substances4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1)and 2,4-diamino-6-phenyl-1,3,5-triazine (CAS no: 91-76-9).The predicted data using the OECD QSAR toolbox has also been compared with the experimental data and summarized as below;
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the skin irritation potential was estimated for test chemical2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) .The chemical 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) is estimated to be not irritating to skin of New Zealand White rabbits.
The IFA GESTIS {GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn)} conducted skin irritation study of read across substance 4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1) on rabbits according to OECD 404 that supports the above mentioned results. The chemical did not produce any adverse skin effects when applied dermally. Therefore under the test condition, the chemical 4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1)was considered to be not irritating to the rabbits’ skin.
The above results were further supported by the dermal irritation study reported by OECD SIDS { SIDS Initial Assessment Report For SIAM 13, OECD SIDS, November 2001} for read across substance 2,4-diamino-6-phenyl-1,3,5-triazine in (CAS no: 91-76-9) on three female New Zealand white albino rabbits in accordance with the OECD Guide-line 404 "Acute Dermal Irritation/Corrosion". The chemical was applied dermally for the 4 hours exposure period under occlusive condition and later observed for skin reactions.No known signs of irritation and systematic toxicity were observed in any of the treated rabbits. Hence,2,4-diamino-6-phenyl-1,3,5-triazine (CAS no: 91-76-9) can be considered to be not irritating to rabbits’ skin.
Thus on the basis of available data for thetarget chemical2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) and its structurally similar read across substances4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1)and 2,4-diamino-6-phenyl-1,3,5-triazine (CAS no: 91-76-9),it can be concluded thatchemical 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) is unable to cause skin irritation and considered as not irritating. Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.
Eye irritation:
In different studies,the test chemical2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) has been investigated for potential for ocular irritationto a greater or lesser extent. The studies are based on in vivo experiments in rabbits for target chemical2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4)its structurally similar read across substances4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1)and 2,4-diamino-6-phenyl-1,3,5-triazine (CAS no: 91-76-9).The predicted data using the OECD QSAR toolbox has also been compared with the experimental data and summarized as below;
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the eye irritation potential was estimated for test chemical2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) .The chemical 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) is estimated to be not irritating to eye of New Zealand White rabbits.
The IFA GESTIS {GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn)} conducted an ocular irritation study of read across substance 4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1) on rabbits according to OECD 405 that supports the above mentioned results.The chemical triggered only minor irritations that subsided within 72 hours when installed into the eyes of each rabbits. Therefore under the test condition, the chemical 4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1)was considered to be not irritating to the rabbits’ eye.
The above results were further supported by an eye irritation study reported by OECD SIDS { SIDS Initial Assessment Report For SIAM 13, OECD SIDS, November 2001} for read across substance 2,4-diamino-6-phenyl-1,3,5-triazine in (CAS no: 91-76-9)on rabbitsas perDirective 84/449/EEC, B.5 "Acute Toxicity (eye irritation)" Guidelines.About 94 mg of undiluted2,4-diamino-6-phenyl-1,3,5-triazine was instilled into eyes of 3 rabbits. The rabbits were observed and scored for signs of irritation at 1, 24, 48 and 72 hours.The mean irritation scores were classifiedfollowing the scheme of Kay and Calandra.In all three animals only the conjunctivae was affected. All effects were reversible within 72 hours (3 day). No effects on the cornea or iris were observed in the treated animals. Treatment of the eyes with fluorescein 24 hours after instillation of the test substance did not reveal any corneal epithelial damage. No signs of systemic toxicity were observed.The mean Draize scores after 1 hour was 4.0 and after 72 hours was 0.0.2,4-diamino-6-phenyl-1,3,5-triazineshould be classified as mildly irritating following thescheme of Kay and Calandra. According to the EEC criteria for classification and labelling,2,4-diamino-6-phenyl-1,3,5-triazineneed not to be labelled as an eye irritant.Hence,2,4-diamino-6-phenyl-1,3,5-triazine (CAS no: 91-76-9) can be considered to be not irritating to rabbit eyes.
Thus on the basis of available data for thetarget chemical2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) and its structurally similar read across substances4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1)and 2,4-diamino-6-phenyl-1,3,5-triazine (CAS no: 91-76-9),it can be concluded thatchemical 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) is unable to cause eye irritation and considered as not irritating. Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.
Justification for classification or non-classification
The skin and eye irritation potential of test chemical 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) and its structurally similar read across substanceswere observed in various studies. The results obtained from these studies indicate that the chemical 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) is unlikely to cause skin and eye irritation. Hence 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS No: 23680-84-4) can be classified under the category “Not Classified” for skin and eye as per CLP.
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