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EC number: 237-525-1 | CAS number: 13826-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- The pyrethroid metabolites 3-phenoxybenzoic acid and 3-phenoxybenzyl alcohol do not exhibit estrogenic activity in the MCF-7 human breast carcinoma cell line or Sprague–Dawley rats
- Author:
- Brian Laffin, Marco Chavez, Michelle Pine
- Year:
- 2 010
- Bibliographic source:
- Toxicology 267 (2010) 39–44
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Details of guideline not mentioned in publication. Uterotrophic assays was performed on rats using 3-phenoxybenzyl alcohol.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 3-phenoxybenzylic alcohol
- EC Number:
- 237-525-1
- EC Name:
- 3-phenoxybenzylic alcohol
- Cas Number:
- 13826-35-2
- Molecular formula:
- C13H12O2
- IUPAC Name:
- (3-phenoxyphenyl)methanol
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): 3-phenoxybenzyl alcohol
- Molecular formula (if other than submission substance): C13-H12-O2
- Molecular weight (if other than submission substance): 200.236 g/mole
- Substance type: Organic
- Physical state: Liquid
- Impurities (identity and concentrations): No data available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Texas A&M University Department of Comparative Medicine
- Age at study initiation: 40–45 days old
- Weight at study initiation: No data available
- Fasting period before study: No data available
- Housing: in controlled conditions
- Use of restrainers for preventing ingestion (if dermal): Not applicable
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C):23°C
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): lights on, 06:00 h, lights off, 18:00 h
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- Gastric intubation
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 3 consecutive days
- Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1.0, 5.0, or 10.0 mg/kg/day
Basis:
no data
- No. of animals per sex per dose:
- randomly assigned to treatment groups
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- No data available
- Positive control:
- a positive control group was subcutaneously injected with ethinyl estradiol (EE, CAS no. 57-63-6, purity 98%) at a dose of 0.6g/kg/day
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: No data available
- Time schedule: No data available
- Cage side observations checked in table [No.?] were included. No data available
DETAILED CLINICAL OBSERVATIONS: No data available
- Time schedule: No data available
BODY WEIGHT: Yes
- Time schedule for examinations: No data available
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study):
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: No data available
- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: No data available FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: No data available
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No data available
- Time schedule for examinations:
No data available
OPHTHALMOSCOPIC EXAMINATION: No data available - Time schedule for examinations: No data available
- Dose groups that were examined: No data available
HAEMATOLOGY: No data available
- Time schedule for collection of blood: No data available
- Anaesthetic used for blood collection: No data available - Animals fasted: No data available - How many animals: No data available
- Parameters checked in table [No.?] were examined. No data available
CLINICAL CHEMISTRY: No data available
- Time schedule for collection of blood: No data available
- Animals fasted: Yes / No / No data No data available
- How many animals: No data available
- Parameters checked in table [No.?] were examined. No data available
URINALYSIS: No data available
- Time schedule for collection of urine: No data available
- Metabolism cages used for collection of urine: No data available
- Animals fasted: No data available
- Parameters checked in table [No.?] were examined. No data available
NEUROBEHAVIOURAL EXAMINATION: No data available - Time schedule for examinations: No data available
- Dose groups that were examined: No data available
- Battery of functions tested: sensory activity / grip strength / motor activity / other: No data available
OTHER: - Sacrifice and pathology:
- Animals were euthanized 24 h after the final dose; and uteri, livers, and kidneys were carefully removed, cleaned of connective tissue, and weighed.
- Other examinations:
- No data available
- Statistics:
- No data available
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Description (incidence and severity):
- No change was observed in control and treated animals liver or kidney weights
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- None of the doses affected uterine wet weight, while EE caused a significant increase in both absolute and relative wet weight (p < 0.001) as compared to animals receiving corn oil only. Additionally, test substance had no effect on liver or kidney weights
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 10 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: No effect on uterine wet weight
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The NOEL (No Observed Effect Level) for 3-phenoxybenzylic alcohol (13826-35-2) was found to be 10 mg/kg/day in a Uterotrophic assay.
- Executive summary:
Repeated dose toxicity test was performed on pups of Sprague–Dawley rats at different concentrations. Adult female rats were bred and allowed to deliver pups normally.Fourteen days post-surgery vaginal lavage was performed daily for 3 consecutive days and cytology was observed to verify animals were not cycling. 3 consecutive days animals received 1.0, 5.0, or 10.0 mg/kg/day concentration of chemical .Animals were euthanized 24 h after the final dose; and uteri, livers, and kidneys were carefully removed, cleaned of connective tissue, and weighed. No change was observed in control and treated animals liver or kidney weights. And it was observed that 3PBAlc are not estrogenic in adult female Sprague–Dawley rats in vivo .
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