Registration Dossier
Registration Dossier
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EC number: 228-726-5 | CAS number: 6337-43-5
Endpoint summary
Administrative data
Description of key information
Skin irritation was tested in a guideline study according to OECD guideline 404 in 3 New Zealand White rabbits. With reference the absence of any effect the substance does not have to be classified as irritant to the skin.
The substance was tested for its eye irritant properties in 3 New Zealand White rabbits. The study was performed according to OECD Guideline 405. Effects onconjunctivae (redness and swelling) were observed in all animals one hour after application. These signs were fully reversible within 72 h.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation: 1 key study available: not irritating
Eye irritation: 1 key study available: not irritating
There is one reliable study on the skin irritancy potential. Skin irritation was tested in a guideline study according to OECD guideline 404 in 3 New Zealand White rabbits.
With reference the reported scores (edema (mean):0, erythema (mean): 0) The substance does not have to be classified as irritant to the skin.
There is one reliable study available on the eye irritancy potential. The substance was tested for its eye irritant properties in 3 New Zealand White rabbits. The study was performed according to OECD Guideline 405.
Effects on conjunctivae (redness and swelling) were observed in all animals one hour after application. These signs were fully reversible within 72 hours.
Justification for selection of skin irritation / corrosion endpoint:
Guideline conform GLP study
Justification for selection of eye irritation endpoint:
Guideline conform GLP study
Justification for classification or non-classification
With reference the reported scores and the reversibility of the effects of effects within 72 h the substance does not have to be classified as irritant to the skin and eyes according to the criteria laid down in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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