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EC number: 247-825-4 | CAS number: 26586-02-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1977-08-09
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment; pre-GLP study with restrictions (only one dose level tested, short observation period, limited examinations).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DOT guidelines
- Deviations:
- yes
- Principles of method if other than guideline:
- The test was carried out according to DOT guidelines. A definite LD50 was not calculated. No further data.
- GLP compliance:
- no
- Remarks:
- pre-GPL study
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- (E)-3-formylbut-2-enyl acetate
- EC Number:
- 247-825-4
- EC Name:
- (E)-3-formylbut-2-enyl acetate
- Cas Number:
- 26586-02-7
- Molecular formula:
- C7H10O3
- IUPAC Name:
- (2E)-3-methyl-4-oxobut-2-en-1-yl acetate
- Details on test material:
- - Name of test material (as cited in study report): beta-formylcrotylacetate (2-methyl-4-acetoxy-butenal)
- Physical state: liquid
- Analytical purity: no data
No further data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
5 male and 5 female albino rabbits
- Weight at study initiation: ca. 2 - 3 kg
- Housing: individually in stainless steel cages; size: (57 cm x 44 cm) x 35 cm
- Diet (ad libitum): pelleted standard diet for rabbits
- Acclimation period: at least 3 days
no further data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 - 23°C
- Humidity (%): 50 - 70%
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: spinal region caudal to the ribs
- % coverage: application area; 7 cm x 7 cm (ca. 50 cm²)
- Type of wrap if used: The treated skin site was covered with a vellum-paper, the vellum-paper was fixed with a cohesive tape (Gazofix (TM))
The skin of the back and flanks of each rabbit was shaved at 2 to 16 hours prior to treatment.
REMOVAL OF TEST SUBSTANCE: no data
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 200 µl/kg bw (ca. 212 mg/kg bw; estimated with a density of 1.605 g/ml) of the unchanged test substance - Duration of exposure:
- 24 hours
- Doses:
- ca. 212 mg/kg bw (200 µl/kg bw)
- No. of animals per sex per dose:
- 5 males and 5 females (only one dose level tested)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 72 hours
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
Mortality was determined at 1, 24, 48 , and 72 hour(s) after beginning of application; local signs of irritation and/or toxicity were monitored. Animals that died spontaneously were subjected to a gross post-mortem examination. - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 212 mg/kg bw
- Remarks on result:
- other: Original value: LD50 > 200 µl/kg bw
- Mortality:
- No deaths occurred.
- Clinical signs:
- other: No clinical signs of toxicity were observed. Local signs: Slight, solid strengthening of the skin, partially cracked and fissured was seen at the application site at 5 days after beginning of the application.
- Gross pathology:
- Pathological examination was not performed since no animal died.
Any other information on results incl. tables
Table: cumulative mortality
Dose |
Concentration |
Animals |
No. of dead animals / no. of exposed animals |
|||
1 h |
24 h |
48 h |
72 h |
|||
200 µl /kg bw (ca. 212 mg/kg bw) |
Undiluted |
Males |
0/5 |
0/5 |
0/5 |
0/5 |
Females |
0/5 |
0/5 |
0/5 |
0/5 |
||
Males + Females |
0/10 |
0/10 |
0/10 |
0/10 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.