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EC number: 203-266-8 | CAS number: 105-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from safety assessment reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- STUDIES ON DERMAL, OCULAR AND RESPIRATORY EFFECTS OF THE TEST MATERIAL IN EXPERIMENTAL ANIMALS
- Author:
- RADOSŁAW ŚWIERCZ ET.AL
- Year:
- 2 000
- Bibliographic source:
- International Journal of Occupational Medicine and Environmental Health, 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Ocular irritation studies were conducted on Chinchilla rabbits to assess the irritation potential of the test chemical
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-ethyltoluene
- EC Number:
- 210-761-2
- EC Name:
- 4-ethyltoluene
- Cas Number:
- 622-96-8
- Molecular formula:
- C9H12
- IUPAC Name:
- 1-ethyl-4-methylbenzene
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report):4-ethyl toluene- Molecular formula :C9H12- Molecular weight:120.194 g/mol- Substance type:Organic- Physical state:LiquidPurity96%- Impurities (identity and concentrations):2-ethyltoluene approx 2.5%, 3-ethyltoluene approx 1.5%.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Chinchilla
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS- Source: Animal Husbandry of The Nofer Institute of Occupational Medicine, Poland- Weight at study initiation: 4.0 + 0.1 kg body weight- Housing: stainless steel cagesENVIRONMENTAL CONDITIONS- Temperature (°C): 20 —23°C- Humidity (%):45 — 60%,- Photoperiod (hrs dark / hrs light): 12-h light/dark cycle(light on from 6 a.m. to 6 p.m.)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 cm3
- Duration of treatment / exposure:
- single exposure
- Observation period (in vivo):
- 1, 24, 48 and 72 h after dosing
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- Details on study designTEST SITE- Area of exposure: conjunctival sacSCORING SYSTEM:The ocular reactions were observed and scored according to the Draize. The eye irritation ratings were: no reaction — 0; slightly irritating — 1 — 16; moderately irritating — 17 — 35; severely irritating — 36 — 75; and extremely irritating - 7 5 - 110
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 110
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Eye changes were minimal, and they were observed no longer than 6 days after application. The Eye Irritation Index was calculated to be 1.7.
Any other information on results incl. tables
The eye irritation index (EII) of rabbits exposed to the test chemical
Time observed in hours | EII |
1 | 2.1 |
24 | 1.8 |
48 | 2.0 |
72 | 0.8 |
EII ()Average) | 1.7 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Eye changes were minimal, and they were observed no longer than 6 days after application. The Eye Irritation Index was calculated to be 1.7.The eye irritation indices after a single exposure of rabbits indicated that the test chemical was a substance with slight irritation effects.
- Executive summary:
Ocular irritation studies were conducted on Chinchilla rabbits to assess the irritation potential of the test chemical. The study was performed as per OECD 405 Guidelines.0.1 cm3 of the test chemical was instilled in the conjunctival sac of a defect-free eye of 3 rabbits. The other eye remained untreated and served as control.The ocular reactions were observed and scored according to the Draize at 1, 24, 48 and 72 hours after dosing.
The eye irritation ratings were: no reaction — 0; slightly irritating — 1 — 16; moderately irritating — 17 — 35; severely irritating — 36 — 75; and extremely irritating - 7 5 – 110.
Eye changes were minimal, and they were observed no longer than 6 days after application. The Eye Irritation Index was calculated to be 1.7.
The eye irritation indices after a single exposure of rabbits indicated that the test chemical was a substance with slight irritation effects.
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