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EC number: 690-512-6 | CAS number: 1271172-98-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to OECD guidelines and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.13/14 (Mutagenicity - Reverse Mutation Test Using Bacteria)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Reaction products of 1,3,5-triazine-2,4,6-triamine and zinc bis(dihydrogen phosphate)
- EC Number:
- 690-512-6
- Cas Number:
- 1271172-98-5
- Molecular formula:
- Zn(C3H7N6)2(P2O7)
- IUPAC Name:
- Reaction products of 1,3,5-triazine-2,4,6-triamine and zinc bis(dihydrogen phosphate)
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA1535, TA97a, TA98, TA100 and TA102
- Details on mammalian cell type (if applicable):
- - Type and identity of media: Vogel Bonner medium 20 fold
- Properly maintained: yes
Genotype confirmation is performed every quarter.
Strain mutations:
TA97a: hisD6610, urvB, pKM 101, rfa
TA98: hisD3052, urvB, pKM 101, rfa
TA100: hisG46, urvB, pKM 101, rfa
TA102: hisG428, pKM 101, rfa
TA1535L hisG46, urvB, rfa
- Metabolic activation:
- with and without
- Metabolic activation system:
- Pre-incubation with S9 mix
- Test concentrations with justification for top dose:
- First test: 51, 151, 500, 1527 and 4995 ug/plate (plate incorporation method)
Second test: 312, 628, 1254, 2528 and 4999 ug/plate (pre-incubation method) - Vehicle / solvent:
- The test substance was suspended in deionised water with all concentrations weighed directly.
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Remarks:
- DMSO control also used
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- sodium azide
- benzo(a)pyrene
- other: 4-Nitro-1,2-phenylene diamine, 2-amino anthracene
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: Plate incorporation method for the first test and pre-incubation method for the repeat test.
DURATION
- Preincubation period: 20 minutes
- Exposure duration: 48 hours
NUMBER OF REPLICATIONS: Per strain and dose, 4 plates with and without S9 mix were used. - Evaluation criteria:
- The colonies were counted visually and numbers recorded. A test substance is considered to have mutagenic potential if a significant, reproducible increase of revertant colonies per plate (increase factor of >/= 2) in at least one strain is observed. A concentration related increase over the range tested can also be taken as a sign of mutagenic activity.
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA 97a, TA 98, TA 100, TA 102 and TA 1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- not examined
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- Confirmation of validity: The treatments conducted for the sterile control and the determination of the titre didn't show any inconsistencies. The determined values for the spontaneous revertants of teh negative controls were in the normal range of the testing laboratory. All positive controls showed positive effects as appropriate.
No signs of toxicity towards the tested strains could be observed. - Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with and without metabolic activation
The test substance is considered as not mutagenic under the conditions of the test.
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