Registration Dossier
Registration Dossier
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EC number: 203-643-7 | CAS number: 109-06-8
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summary of a study in a review article.
Data source
Reference
- Reference Type:
- publication
- Title:
- Brain Slice Techniques in Neurotoxicology
- Author:
- Fountain S.B. and Teyler T.J.
- Year:
- 1 995
- Bibliographic source:
- Neurotoxicology, approaches and methods chapter 31, 517-535, Academic Press
Materials and methods
- Principles of method if other than guideline:
- Central nervous tissue slices in vitro (hippocampal slices) were tested for neurotoxicity screening. Different isomeric methylpyridines were tested.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methylpyridine
- EC Number:
- 203-643-7
- EC Name:
- 2-methylpyridine
- Cas Number:
- 109-06-8
- Molecular formula:
- C6H7N
- IUPAC Name:
- 2-methylpyridine
- Details on test material:
- - Name of test material (as cited in study report): 2-methylpyridine
Constituent 1
Test animals
- Species:
- other: rat hippocampal slices
Administration / exposure
- Duration of treatment / exposure:
- 3 hour
- Details on study design:
- Central nervous tissue slices in vitro (hippocampal slices) were tested for neurotoxicity screening. Different isomeric methylpyridines, among which the test substance were tested.
Results and discussion
Results of examinations
- Details on results:
- Exposure to the test substance produced approximatly 30 - 40 % suppression of EPSP (excitatory postsynaptic potential).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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