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EC number: 203-721-0 | CAS number: 109-94-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity and Teratogenicity of Food Additive Chemicals in the Developing Chicken Embryo
- Author:
- M. JACQUELINE VERRETT et al
- Year:
- 1 980
- Bibliographic source:
- TOXICOLOGY AND APPLIED PHARMACOLOGY (1980)
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Teratogenicity of test Chemicals was performed in the Developing Chicken Embryo
- GLP compliance:
- not specified
- Type of method:
- in vitro
Test material
- Reference substance name:
- Ethyl formate
- EC Number:
- 203-721-0
- EC Name:
- Ethyl formate
- Cas Number:
- 109-94-4
- Molecular formula:
- C3H6O2
- IUPAC Name:
- ethyl formate
- Details on test material:
- - Name of test material: Ethyl formate
- Molecular formula: C3H6O2
- Molecular weight: 74.0784 g/mol
- Smiles notation: O(CC)C=O
- InChI: 1S/C3H6O2/c1-2-5-3-4/h3H,2H2,1H34H3;1H
- Substance type: organic
- Physical state: liquid
Constituent 1
Test animals
- Species:
- other: Chicken
- Strain:
- other: Single-Comb White Leghorn
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data avilable
Administration / exposure
- Route of administration:
- other: Injection (Via Yolk and via air cell injection)
- Vehicle:
- not specified
- Details on exposure:
- No data avilable
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- At two stages of incubation: preincubation (0 hr) and at the fourth day (96 hr)
- Frequency of treatment:
- At 0h and 96 h
- Duration of test:
- 96 h
Doses / concentrations
- Remarks:
- 0.50 to 75 mg/egg (5 dose level)
- No. of animals per sex per dose:
- 500 eggs (100 eggs per dose)
- Control animals:
- yes
- Statistics:
- No data avilable
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 25 other: mg/egg
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: No teratogenic effect were observed
- Remarks on result:
- other: No teratogenic effect were observed
Observed effects
Applicant's summary and conclusion
- Conclusions:
- The NOAEL value for teretogenicity of test chemical was considered to be 25 mg/egg in chicken embryo.
- Executive summary:
Teretogenicity study of test chemical was conducted in Fresh fertile eggs from Single-Comb White LeghornChicken.Test chemical was administered by two routes, into tha yolk and through the air cell. For each enjection route, eggs were treated at0h and at 96 h. Five dose level tested range from 0.50 to 75 mg/egg and 100 embryos were treated per dose. Mortality, abnormalities included
all structural anomalies as well as toxic responses such as edema, hemorrhage, hypopigmentation of the down, significant growth retardation, cachexia, and other nerve disorders.Structural abnormality of the head, viscera, limbs, or body skeleton were examined. No teretogenic effect observed at dose level of 25 mg/egg. Hence,the NOAEL value for teretogenicity of test chemical was considered to be 25 mg/egg in chicken embryo.
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