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Diss Factsheets
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EC number: 930-776-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Mn3O4 has low oral toxicity when given to adult rats over a sub-acute period. Mn3O4 has been demonstrated to have low toxicity at low air concentrations (equivalent to 1 mg respirable Mn/m3) (Ulrich et al 1979). No dermal studies are available, but absorption of Mn3O4 through skin is not expected based on its very poor solubility in water.
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Classification by the oral route is not justified based on the lack of significant toxicity observed in the 28 day study (IUCLID 7.5.1) and acute oral toxicity study (IUCLID section 7.2.1)
Mn3O4 is mostly used in industrial settings where good industrial hygiene is employed. Therefore, this is not a likely route of exposure. However, in the unlikely event of accidental consumption, the acute oral toxicity test confirms no evidence of toxicity via this route.
Classification by the inhalation route is not justified because leaching in artificial lung fluid is very low , hence systemic exposure will also be very low. The very poor solubility in water (0.79 mg/L, see IUCLID section 4.8) is likely to mean that a significant percentage of any particles inhaled will undergo mucociliary escalation back into the gastro-intestinal tract where there is a low level of oral toxicity.
An investigation on the bioavailability of the registered substance in artificial lung fluid demonstrates the low bioavailability of the substance in the lungs (0.000047%, see IUCLID section 7.12). To support this, Mn3O4 is not acutely toxic by the inhalation route ( IUCLID section 7.2.2).
Classification by the dermal route is not justified due to the very poor water solubility of Mn3O4 and hence a minimal amount of the potential substance is made available for systemic absorption via the dermal route.
Even if minimally available from exposure, the physiological properties of the registered substance do not indicate a significant rate of absorption through the skin. Furthermore, there were no systemic effects or any other evidence of absorption seen in the skin and eye irritation studies .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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