Laurus nobilis, ext.

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

2007

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given, but considered sufficiently reliable for the purpose of hazard assessment

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

2007

Materials and methods

Type of sensitisation studied:

skin

Study type:

other: case report and patch testing

Principles of method if other than guideline:

A 36-year-old non-atopic man presented with generalized erythematous and oedematous dermatitis being more severe at the back and dorsal aspect of the legs. Two weeks earlier, he had undergone a massage with a mixture of olive oil and L. nobilis (laurel) oil on his back, thighs and dorsal aspect of the limbs and after 3 days of application dermatitis had appeared and gradually spread to the rest of the body. He had once used L. nobilis (laurel) oil to his knee under occlusion to relieve pain. He was treated with antihistamine and corticosteroid and the lesions started to heal, leaving post-inflammatory hyperpigmentation. Six weeks later, patch testing was performed with a European standard series, patient’s own products, suspected massage oils – laurel oil, olive oil and the mixture of olive and L. nobilis (laurel) oil.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Laurus nobilis, ext.

EC Number:

283-272-5

EC Name:

Laurus nobilis, ext.

Cas Number:

84603-73-6

IUPAC Name:

Laurus nobilis, ext.

Test material form:

not specified

Details on test material:

- Name of test material (as cited in study report): Laurel oil

Method

Type of population:

general

Controls:

None

Route of administration:

dermal

Results and discussion

Results of examinations:

- Patch testing showed (+++) reactions to laurel oil and (++) to the mixture of olive oil and laurel oil.

Any other information on results incl. tables

None

Applicant's summary and conclusion

Conclusions:

Under the test conditions, patch testing with laurel oil showed sensitisation reactions in man.

Executive summary:

In a study, a 36-year-old non-atopic man presented with generalized erythematous and oedematous dermatitis being more severe at the back and dorsal aspect of the legs. Two weeks earlier, he had undergone a massage with a mixture of olive oil and L. nobilis (laurel) oil on his back, thighs and dorsal aspect of the limbs and after 3 days of application dermatitis had appeared and gradually spread to the rest of the body. He had once used L. nobilis (laurel) oil to his knee under occlusion to relieve pain. He was treated with antihistamine and corticosteroid and the lesions started to heal, leaving post-inflammatory hyperpigmentation. Six weeks later, patch testing was performed with a European standard series, patient’s own products, suspected massage oils – laurel oil, olive oil and the mixture of olive and L. nobilis (laurel) oil.

 

Patch testing showed (+++) reactions to laurel oil and (++) to the mixture of olive oil and laurel oil.

 

Under the test conditions, patch testing with laurel oil showed sensitisation reactions in man.