Registration Dossier
Registration Dossier
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EC number: 242-171-6 | CAS number: 18293-82-8
Endpoint summary
Administrative data
Description of key information
Additional information
There are no reliable aquatic toxicity data available for isobutyl(dimethoxy)methylsilane (CAS 18293-82-8), therefore good quality data for structurally-related substances, isobutyl(trimethoxy)silane (CAS 18395-30-7) and 3-chloropropyl(diethoxy)methylsilane (CAS 13501-76-3), have been read across based on a weight of evidence approach.
Reliable short-term toxicity tests results are available for invertebrates (Daphnia magna) and algae (Scenedesmus subspicatus (new name: Desmodesmus subspicatus)) for isobutyl(trimethoxy)silane (CAS 18395-30-7). The relevant short-term values are:
Daphnia: EC50 (48 h): >864 mg/l; NOEC: ≥295 (or EC50 (48 h): >660 mg/l; NOEC: ≥660 mg/l when expressed in terms of concentration of the hydrolysis product, (2-methylpropyl)silanetriol).
Algae: EC50 (72 h): >1170 mg/l; NOEC: 221 mg/l (or EC50 (72 h): >894 mg/l; NOEC: 169 mg/l when expressed in terms of concentration of the hydrolysis product, (2-methylpropyl)silanetriol).
The rapid hydrolysis of isobutyl(trimethoxy)silane (CAS 18395-30-7) (half-life 4.1 h at pH 7 and 20-25 °C) means it is likely that the test organisms in each test were exposed primarily to the hydrolysis products, (2-methylpropyl)silanetriol and methanol.
Reliable short-term toxicity tests results are available for invertebrates (Daphnia magna) and algae (Scenedesmus subspicatus (new name: Desmodesmus subspicatus)) for 3-chloropropyl(diethoxy)methylsilane (CAS 13501-76-3). The relevant short-term values are:
Daphnia: EC50 (48 h): 295 mg/l; NOEC: 160 mg/l (or EC50 (48 h): 216 mg/l; NOEC: 117 mg/l when expressed in terms of concentration of the hydrolysis product, (3-chloropropyl)(methyl)silanediol).
Algae: EC50 (72 h): 437 mg/l; NOEC: 57 mg/l (or EC50 (72 h): 321 mg/l; NOEC: 42 mg/l when expressed in terms of concentration of the hydrolysis product, (3-chloropropyl)(methyl)silanediol).
The rapid hydrolysis of 3-chloropropyl(diethoxy)methylsilane (CAS 13501-76-3) (half-life 9.5 h at pH 7 and 20-25 °C) means it is likely that the test organisms in each test were exposed primarily to the hydrolysis products, (3-chloropropyl)(methyl)silanediol and ethanol.
Refer to IUCLID Section 6 endpoint summary for further discussion of the approach to chemical safety assessment and justification for read-across.
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