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Diss Factsheets
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EC number: 200-386-2 | CAS number: 58-56-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No rough data are included (calculated LD values only). No data on number of animals tested per concentration. No details on clinical signs or gross pathology. The test was performed in mice. Observation time limited to 10 days.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Male and female mice were exposed to three different concentration of the test substance and observed for at least ten days.
- GLP compliance:
- no
- Test type:
- other: no details on study design
- Limit test:
- no
Test material
- Reference substance name:
- Pyridoxine hydrochloride
- EC Number:
- 200-386-2
- EC Name:
- Pyridoxine hydrochloride
- Cas Number:
- 58-56-0
- Molecular formula:
- C8H11NO3.ClH
- IUPAC Name:
- 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Pyridoxine hydrochloride
- Lot No.: 258001, 258002, 258241, 248242, 258409, 258410, 258464, 258505, 258506, 258732
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 18-22 g
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Details on oral exposure:
- Animals were observed for at least 10 days.
- Doses:
- 3500, 7000 and 14000 mg/kg bw
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- Ten batches were tested.
- Statistics:
- OLIVETTI calculator was used to detrmine LD values.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 6 994 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 10 day observation period; calculated value
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 3 344 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 10 day observation period
- Mortality:
- One animals died within 24 hours, some animals died after the first 24 hours but within the observation time of 10 days.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral toxicity of ten batches of pyridoxine-hydrochlorid was tested in mice. After 10 days observation period, the LD0 was found to be 3344 mg/kg bw. The LD50 was calculated based on results of 10 batches and found to be 6994 mg/ kg bw.
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