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Diss Factsheets
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EC number: 433-180-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-04-14 to 1999-04-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to EU test method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Details on test material:
- - Name of test material (as cited in study report): Reaktiv-Orange DYPR934
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- -6.1
- Temp.:
- 20 °C
- Details on results:
- See below.
Any other information on results incl. tables
Determination of the saturation concentration of Reaktiv-Orange in n-octanol
For the determination of the n-octanol solubility four weighed portions (29.462 mg, 29.240 mg, 28.164 mg and 31.268 mg) of the test substance were added to 50 ml of n-octanol and stirred for 3 h at 20 °C.
Every solution was treated as follows:
One aliquot of about 8 mL were taken, centrifugated (15 min, 5000 rpm) and the centrifugates were filtered (Schleicher + Schüll 0.2 µm). 2 mL of n-octanol filtrates were extracted with 2 mL of distilled water, centrifugated (1 min, 5000 rpm) and the aqueous phase was investigated by HPLC.
Solubility in n-octanol:
Average 0.45 mg/L (corrected for purity of 56 %: 0.25 mg/L)
Standard deviation: 0.18 mg/L
The determination was performed as sum of both main components.
Final results:
Pow = 8.47 x 10-7
Log Pow = -6.07
Exp. |
Stirring time (h) |
Concentration (mg/L) |
Peak areas1) |
Mean value Peak areas1) |
n-octanol solubility (mg/L) |
Standard G1 |
|
1.2704 |
17.241 16.211 |
16.726 |
|
Exp.3 |
3 |
|
2.583 3.154 |
2.869 |
0.22 |
Standard H1 |
|
0.6588 |
8.419 7.886 |
8.153 |
|
Exp. 4 |
3 |
|
7.933 7.702 |
7.818 |
0.63 |
Standard I1 |
|
0.7376 |
8.288 12.035 |
10.162 |
|
Exp.5 |
3 |
|
5.133 5.839 |
5.486 |
0.40 |
Standard J1 |
|
0.7846 |
12.004 13.406 |
12.705 |
|
Exp.6 |
3 |
|
8.864 8.585 |
8.725 |
0.54 |
1)sum of main components |
Applicant's summary and conclusion
- Conclusions:
- The n-octanol/ water partition coefficient of the test substance determined from its solubility in water and in n-octanol will be:
Log Pow = -6.07 - Executive summary:
In a GLP compliant study the partition coefficient of Reactive-Orange DYPR 934 was determined from the ratio of the saturation concentrations of the test item in both n-octanol and water. The saturation of Reaktiv-Orange DYPR 934 in water was determined as to be 295.28 g/L (project EO 003 -99) while the determination of the saturation concentration of Reaktiv-Orange DYPR 934 in n-octanol was quantified by comparing integrated peak areas measured by injection of solutions with known amounts of the test substance (external standard method).
The n-octanol / water partition coefficient of the test substance determined from its solubility in water and in n-octanol will be:
Log Pow = -6.07
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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