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EC number: 442-640-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
A study was performed according to EU method C.7 and in compliance with GLP to measure the rate of hydrolysis of the test substance Reactive Olive F00-0149. At pH 7 the rate constant at 38°C was calculated to 7.147E-03 h-1 and the corresponding half-life of the test substance was 26.92 h at pH 7 and 42.55 hours at pH 4. The half-life at 25 °C was not determined within the study. However, the rate constant at 25 °C was extrapolated using the Arrhenius equation, and the corresponding half-life calculated during subsequent study evaluation following the EU Technical Guidance Document on Risk Assessment. The calculated half-life time is 76.16 hours at 25°C.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 76.16 h
- at the temperature of:
- 25 °C
Additional information
The hydrolysis rate of the test substance was determined in accordance with EU method C.7, and in compliance with GLP. The test substance was dissolved in standard buffer (~ 2 g/l) and its concentration measured at specific sampling times. HPLC was used to analyse the test substance concentration. A preliminary test was carried out to assess the rate of hydrolysis at pH 4, 7 and 9 at 50 °C; as a consequence, the main test at pH 9 were not performed due to low hydrolysis at pH 9.
The main test was carried out at pH 4 and 7 at 50 °C initially. A linear dependence of the log10-transformed test substance concentration on time was observed, i.e. the hydrolysis followed pseudo first order kinetics. Therefore, further tests were carried out at pH 4 and 7 at 38 °C. From the measurement results the rate constants and the half-lives of the test substance were calculated at:
pH 4, 50 °C: Kobs = 0.0317 h-1, t1/2 = 21.89 hours
pH 4, 38 °C: Kobs = 0.0163 h-1, t1/2 = 42.55 hours
pH 7, 50 °C: Kobs = 0.0767 h-1, t1/2 = 9.04 hours
pH 7, 38 °C: Kobs = 0.0257 h-1, t1/2 = 26.92 hours
The Arrhenius equation was used to calculate the rate constant at 25 °C. At pH 7 the rate constant was calculated at 7.147 ×10-3h-1.
The half-life for the test substance at pH 7 and 25 °C was not determined and not extrapolated within the study.
For this reason equation 25 from the Technical Guidance Document on Risk Assessment Part II from the Institute for Health and Consumer Protection - European Chemicals Bureau was used do derive the half-life value at 25°C:
DT50(X°C) = DT50(T) * e^(0.08*(T-X))
DT50(X°C) = Half-life time at desired temperature (here: X = 25°C)
DT50(T) = Half-life time at measured temperature (here: T = 38°C)
T = 38°C, X = 25°C.
The resulting calculated half-life time is 76.16 hours at 25°C.
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