Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-302-7 | CAS number: 80-70-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Significant accumulation of 1,1,3,3 -Tetramethylguanidine (CAS 80 -70 -6) in organisms is not to be expected.
Key value for chemical safety assessment
Additional information
QSAR-disclaimer:
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of 1,1,3,3-Tetramethylguanidine (CAS 80-70-6) (Q)SAR results were used for aquatic bioaccumulation. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, and for reasons of animal welfare, further experimental studies on aquatic bioaccumulation are not provided.
Assessment:
In accordance with column 2 of REACH Annex IX the study does not need to be conducted since the substance has a log Kow less or equal than 3. The substance has a log Kow of -0.49 (measured, Lonza, rep.no.: 698-107-1136, 2015). In order to assess the bioaccumulation potential of the test substance, the BCF was calculated with several estimation models. The table below lists the applied (Q)SAR models, the estimated BCF values and basic information on the applicability domain (AD) for the compound. Detailed information on the model’s results and the AD are given in the endpoint study records of IUCLID Chapter 5.3.1. The selected models comply with the OECD principles for (Q)SAR models.
Summary of relevant information on aquatic bioaccumulation: Predicted BCF values for applied QSAR models sorted by BCF:
(AD = Applicability Domain)
Model |
BCF [L/kg] |
In AD |
Restraints |
US EPA T.E.S.T. v4.2.1: Bioaccumulation: Consensus method
|
0.74 |
Yes |
Based on the mean absolute errors of the models compared to the training set data, the confidence in the predicted results is low. |
BCF KNN/Read-Across v1.1.0 (VEGA v1.1.3) |
0.66 |
No |
Only moderately similar compounds with known experimental value in the training set have been found |
BCFBAF v3.01 (EPI Suite v4.11):Arnot-GobasBCF, upper trophic, incl. biotransformation
|
0.92 |
No |
The substance appreciably ionizes at physiologically relevant pH |
BCFBAF v3.01 (EPI Suite v4.11):Arnot-GobasBCF, upper trophic, incl. biotransformation of zero
|
0.93 |
No |
The substance appreciably ionizes at physiologically relevant pH |
CAESAR v2.1.14 (VEGA v1.1.3)
|
2 |
No |
- No similar compounds with known experiental value in the training set have been found - Some atom centered fragments of the compound have not been found in the compounds of the training set or are rare fragments (2 in frequent fragments found). - The model detected one structural allert (tertiary amine SR05 group).This group has been found to be present in a large number of nonbioaccumulative compounds (28), even when the log Kow value was higher than 3. |
Meylan v1.0.3 (VEGA v1.1.3) |
3 |
No |
- No similar compounds with known experimental value in the training set have been found - A prominent number of atom centered fragments of the compound have not been found in the compounds of the training set or are rare fragments (1 unknown fragments and 1 infrequent fragments found) |
BCFBAF v3.01 (EPI Suite v4.11): Meylan et al. (1997/1999)
|
3.16 |
Yes |
- |
Considering all models applied 1,1,3,3-Tetramethylguanidine (CAS 80-70-6), the estimated BCF values range from 0.66 to 3.16 L/kg.
The US EPA T.E.S.T. calculation model was in the AD, but, based on the mean absolute errors of the models compared to the training set data, the confidence in the predicted results is low. The estimation of BCFBAF v3.01 model according Meylan et al. was also within the AD of the molecule.
Based on the available information on the log Kow (log Kow = -0.49; measured; Lonza Ltd, 2015, see IUCLID Ch. 4.7) and supported by a weight-of-evidence approach from calculated data it can be concluded that significant accumulation of 1,1,3,3 -Tetramethylguanidine (CAS 80 -70 -6) in organisms is not to be expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.