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Diss Factsheets
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EC number: 608-251-3 | CAS number: 287930-77-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 29 to May 19, 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to OECD and in accordance with GLP. The study material is well characterize
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 bis (Acute Oral Toxicity - Fixed Dose Procedure)
- Version / remarks:
- July 1992
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- GLP compliance:
- yes
- Remarks:
- OECD Principles of Good Laboratory Practice, Statutory Instrument No. 654, 1997, ISBN 0-11-064105-1
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- (1S)-1-[3-[(1E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propanol
- EC Number:
- 608-251-3
- Cas Number:
- 287930-77-2
- Molecular formula:
- C29H28NO2Cl
- IUPAC Name:
- (1S)-1-[3-[(1E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propanol
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- White powder, stored in dark at ambient temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River UK., Margate, Kent, England
- Age at study initiation: 7 - 8 weeks
- Weight at study initiation: 175 - 232g
- Fasting period before study: overnight
- Housing: The dose range-finding animal was housed singly in a cage with dimensions 42 x 27 x 20 cm, and the main study animals were housed 5 per cage per sex with dimensions 59 x 38.5 x 20 cm
- Diet: Rat and Mouse No. 1 Maintenance Diet, supplied by Special Diets Services Limited, 1 Stepfield, Witham, Essex, CMS 3AD was available ad libitum throughout the study except for a period of food deprivation overnight prior to dosing until as soon as practicable after dosing.
- Water: Domestic mains quality water was available ad libitum throughout the study
- Acclimation period: 5 days before commencement of study
ENVIRONMENTAL CONDITIONS
- Temperature (°C): During the study, mean environmental maximum and minimum temperatures were 22°c and 19°C
- Mean Humidity (%): 50 %
- Air changes (per hr): 15 minimum
- Photoperiod (hrs dark / hrs light):12/24
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Details on oral exposure:
- The available toxicity data suggested that an initial dose level of 2000 mg/kg would be suitable. The main study dose level was selected based on the results from the dose range-finding study.
The test material was administered orally in a single dose by means of a gavage at a constant dose volume of 10 ml/kg.
The dose was calculated based on the weight of the animal on the day of dosing. - Doses:
- dose level: 2000 mg/kg
- No. of animals per sex per dose:
- A preliminary dose range-finding, using one female, at 2000 mg/kg indicated that this dose level would be suitable for the main study. 5 females and 5 males were used for this main study.
- Control animals:
- no
- Details on study design:
- The dose was calculated based on the weight of the animal on the day of dosing.
Formulations were administered within approximately 1 hour of preparation and were magnetically stirred during dosing.
All the animals were checked for viability early in the morning and again as late as possible on each day until sacrifice on Day 8 (dose range-finding) or Day 15 (main study). - Statistics:
- No formal statistical analysis was conducted
Results and discussion
- Preliminary study:
- The available toxicity data suggested that an initial dose level of 2000 mg/kg would be suitable. The main study dose level was selected based on the results from the dose range-finding study.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no premature decedents during the study
- Clinical signs:
- other: Clinical signs were noted from approximately 5 to 6 hours after dosing and on Day 2. These signs were limited to wet, stained perigenital area and soft jelly like faeces
- Gross pathology:
- There were no abnormalities detected at necropsy.
Dose Level
(mg/kg) Animal/Sex Necropsy Finding Day of Death
2000 6-10male No abnormalities detected 15
11-15 female No abnormalities detected 15
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study following a single oral administration of L-744,341 to Sprague-Dawley rats, no mortality and no toxicity occurred at 2000 mg/kg
- Executive summary:
There were no premature decedents or major clinical signs noted during the obsevation period.
Body weight performance was considered to be satisfactory, and there were no abnormalities detected at necropsy.
Under the conditions of the study following a single oral administration of L-744,341 to Sprague-Dawley rats, no mortality and no toxicity occurred at 2000 mg/kg
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