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EC number: 203-109-3 | CAS number: 103-41-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
- Objective of study:
- metabolism
- other: enzymatic hydrolysis
- Principles of method if other than guideline:
- In vitro hydrolysis procedure using preparation of pancreatin.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzyl cinnamate
- EC Number:
- 203-109-3
- EC Name:
- Benzyl cinnamate
- Cas Number:
- 103-41-3
- Molecular formula:
- C16H14O2
- IUPAC Name:
- benzyl 3-phenylacrylate
Constituent 1
Test animals
- Species:
- other: origin of the pancreatin preparation is unclear
- Strain:
- not specified
Administration / exposure
- Route of administration:
- other: not applicable as it is an in vitro study
- Details on study design:
- The test material was incubated in 0.5 M phosphate buffer at pH 7.5 and 37° C with preparation of pancreatin (Merck 7132). The extent of hydrolysis was determined after 2 h by gas--liquid chromatography of the ester.
Results and discussion
Main ADME results
- Type:
- other: % hydrolysis
- Results:
- 80
Metabolite characterisation studies
- Metabolites identified:
- no
Any other information on results incl. tables
The author showed that the substance hydrolyses rapidly in vitro and presumed that because of this the ester will also be degraded readily in the intact animal.
Ester |
Conc (µL/L) a |
GLC column used for |
% Hydrolysis |
|
Ester |
Alcohol |
|||
Test item |
18 mg/L e |
Dexsil 300 |
Carb 20 M |
80 |
a concentration in incubation mixture in µL/L unless otherwise stated
e esters dissolved in ethanol initially and then diluted with water
Applicant's summary and conclusion
- Conclusions:
- The ester was hydrolysed rapidly by pancreatin in vitro.
- Executive summary:
The study is a preliminary investigation using an in vitro hydrolysis procedure designed to establish the relative rates of enzymic hydrolysis of the ester. The test substance was incubated with a preparation of pancreatin (Merck 7132) in 0.5 M phosphate buffer at pH 7.5 and 37° C. Incubations were made under arbitrary experimental conditions and the extent of hydrolysis of the ester by pancreatin was determined after 2 h by gas-liquid chromatography. The test substance showed 80% hydrolysis under the conditions of the experiment, indicating that the ester hydrolyses rapidly by pancreatin.
The author presumes that esters hydrolysing rapidly in vitro, will also be degraded rapidly in the intact animal.
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