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Diss Factsheets
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EC number: 406-370-3 | CAS number: 58890-25-8 MDI/CHA
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
A toxicokinetic assessment was performed based on the available data of the substance. For risk assessment purposes, 10% is used for oral and dermal absorption, 100% for inhalation absorption.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 10
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 100
Additional information
The water solubility of MDI/CHA is very low (<1 mg/L).Since in general a substance needs to be dissolved before it can be taken up from the gastro-intestinal tract, it is unlikely that MDI/CHA will show a high systemic exposure after oral administration. The absorption will furthermore be lowered by the relatively large molecular weight (448 g/mol) of this substance limiting the passage through biological membranes. Its lipophilic character indicates that uptake by micellular solubilisation may be of importance. For risk assessment purposes the oral absorption of MDI/CHA is set at 10%. The results of the toxicity studies do not provide reasons to deviate from this proposed oral absorption factor.
In the gastro-intestinal tract the amide-bond might be cleaved by amidases.Absorbed MDI/CHA might undergo aliphatic and aromatic hydroxylation and conjugation (1). Because of the reduced molecular weight after cleaving the amide-bond, the conjugates will either be excreted via the bile or the
urine.
Based on the particle size of MDI/CHA, particles < 100 μm which have a potential to be inhaled, are present. Particles will either settle in the
nasopharyngeal region (particles with aerodynamic diameter > 1-5 μm) or in the tracheobronchial or pulmonary region (particles with aerodynamic diameter < 1-5 μm). The low water solubility of MDI/CHA indicates a potential for accumulation, while its lypophilic character indicates the potential for absorption directly across the respiratory tract epithelium. For risk assessment purposes the inhalation absorption of MDI/CHA is set at 100% as a worst case assumption.
MDI/CHA being a solid with a relatively high molecular weight has no real potential for dermal absorption. Furthermore, its low water solubility and lipophilic character do not facilitate dermal absorption. Although the criteria for 10% dermal absorption as given in the TGD (MW > 500 and logPow > 4) are not met, 10% dermal absorption of MDI/CHA is proposed for risk assessment purposes in view of its solid form, low water solubility and as it is generally accepted that dermal absorption is equal or lower compared to oral absorption for non-irritating substances. The results of the toxicity studies do not provide reasons to deviate from this proposed dermal absorption factor.
Based on the present available data, no additional conclusions can be drawn on the distribution, metabolism and excretion of MDI/CHA after dermal and inhalatory absorption.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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